While the Hornets finished in 19th position in the Premier League last season, Boro claimed 17th spot at the second tier after a late-season surge up the standings.
With Nigel Pearson having been removed from his position at the end of last season, it was inevitable that Watford would bring in a new man in the dugout ahead of what feels like a new era for the club.
Their chosen replacement is Vladimir Ivic, a man who has enjoyed success at both PAOK and Maccabi Tel Aviv, and Hornets supporters will feel optimistic that most things are in place to have a successful season.
Ivic will no doubt be provided with the funds to further strengthen a squad in transition, although the Serbian will already be encouraged by a pre-season victory over Tottenham Hotspur.
Despite the likely activity behind the scenes, Ivic will be fully focused on trying to get the better of opponents who head into the season in mixed shape.
As it stands, Neil Warnock has not managed to find replacements for a number of experienced heads who have all left the Riverside Stadium on a free transfer.
Nevertheless, having followed a pre-season thumping of Newcastle United with a thrilling 4-3 victory over Shrewsbury Town in the EFL Cup, the veteran boss will be excited to work with this group of players going forward.
Warnock will insist, however, that any expectations regarding a playoff bid are lowered, despite a return of 12 points from his opening eight matches at the end of last season.
The duo already have five goals apiece since his arrival back in June, and any future success for the club may be dependent on the front pairing maintaining their current ratio.
Watford form (pre-season friendlies): LWW
Middlesbrough form (all competitions): W
Andre Gray will play no part for Watford this weekend after sustaining an injury during last weekend's meeting with Spurs.
Francisco Sierralta, who came off the substitutes' bench against Spurs, may also make his debut after signing from Udinese on Wednesday.
Middlesbrough boss Warnock is unlikely to make many alterations to the team which started against Shrewsbury.
There will be at least one change in the squad due to youngster Sam Stubbs being allowed to link up with Fleetwood Town.
Watford possible starting lineup:
Foster; Dawson, Kabasele, Wilmot; Ngakia, Chalobah, Cleverley, Estupinan; Dele-Bashiru, Quina; Murray
Middlesbrough possible starting lineup:
Stojanovic; Dijksteel, Hall, Fry; Spence, Howson, Wing, Tavernier, Johnson; Fletcher, Assombalonga
We say: Watford 2-1 Middlesbrough
While Boro have gotten a competitive 90 minutes under their belt, they were far from convincing against lower-league opponents. With that in mind, we are backing the home side to get off to a winning start, potentially with a hard-fought win which features a late strike.