Zinedine Zidane's side won their 34th La Liga title last season and just their second since 2011-12, largely due to their sensational form after the lockdown period.
Madrid's involvement in the latter stages of the Champions League means that they were given an extra week to recover before starting their season, and the champions will be determined to begiun with a victory.
Here, Sports Mole looks at how the visitors could line up this weekend.
Madrid will be without a number of players for their opening match of the season, with attacking trio Eden Hazard, Marco Asensio and Isco all on the sidelines through injury.
Lucas Vazquez, meanwhile, has a muscular problem and will not feature, while Mariano Diaz is not available, having undergone surgery for tonsillitis.
Eder Militao is also a doubt due to a muscular problem that he picked up in Wednesday's pre-season clash with Getafe, but Luka Jovic and the returning Martin Odegaard both trained on Friday and could be involved.
Zidane also has the option of bringing in another midfielder, though, with Federico Valverde on standby, which would likely see either Vinicius or Rodrygo feature alongside Benzema in a front two.