The hosts were held to a 1-1 draw by Nimes in their most recent outing, while Saint-Etienne suffered their first defeat of the campaign at home to table-toppers Rennes in gameweek five.
Lens had put together a three-game winning streak prior to their clash with Nimes, including impressive victories over Paris Saint-Germain and Bordeaux, but Franck Haise's men were unable to take all three points against Les Crocodiles last Sunday.
Even though Lens failed to keep their winning run going, Haise should still be delighted by the way his side have gone about their business since suffering an opening-day defeat to Nice.
Lens will now look to maintain their 100% record at home since achieving promotion back to the big time, although they will be welcoming a Saint-Etienne side desperate to get back to winning ways following a couple of underwhelming results.
Saint-Etienne and Rennes faced off in the pick of the fixtures in gameweek five, and given the respective form of the two sides, the clash had all the makings of a truly entertaining and closely-fought affair.
Puel's side had been forced to settle for a 2-2 draw against Nantes prior to the defeat to Rennes, so the Saint-Etienne faithful will be hoping that this is not the start of a slippery slope for their team after such a promising start to their campaign.
As things stand, Saint-Etienne sit fourth and Lens occupy sixth spot, but the two sides are only separated in the table by a solitary goal heading into Saturday's showdown.
Lens and Saint-Etienne have not locked horns since the 2014-15 campaign, where Les Verts enjoyed a 1-0 victory at Lens before the points were shared in a six-goal thriller in the corresponding fixture.
Lens Ligue 1 form: LWWWD
Saint-Etienne Ligue 1 form: WWWDL
Ganago, who sits atop the scoring charts alongside Lyon's Memphis Depay, should be fine for this encounter after his injury scare against Nimes.
Lens possible starting lineup:
Leca; Medina, Bade, Gradit; Clauss, Doucoure, Cahuzac, Haidara; Kakuta; Ganago, Sotoca
Saint-Etienne possible starting lineup:
Moulin; Sissoko, Moukoudi, Kolodziejczak, Macon; Neyou, Youssouf; Bouanga, Aouchiche, Nordin; Hamouma
We say: Lens 0-1 Saint-Etienne
Lens have performed extremely well in the opening weeks of the season and already look like a side capable of cementing their Ligue 1 status for next season. However, Saint-Etienne will be desperate to return to winning ways and have a point to prove following their crushing defeat to Rennes, so we expect the visitors to just edge this one.