The home side come into this one in good form, having won their last three matches in all competitions, whereas Rio Ave have so far struggled to replicate their strong 2019-20 showing.
Former Sheffield Wednesday and Swansea City manager Carlos Carvalhal is now at the helm at the Estadio Municipal de Braga after guiding Rio Ave to their record points total last campaign.
Carvalhal will be hoping to bring some much-needed stability to Os Arcebispos during his second stint with the Portuguese outfit after the club went through a raft of head coaches in a turbulent, albeit successful, 2019-20.
A 2-1 loss away to Belenenses at the start of the month is Braga's only defeat in their last nine outings across the league and multiple cup competitions in what has been a strong start to the season.
Eighteen points from their opening nine top flight games have left them in fourth position ahead of this midweek encounter, with their only other domestic deficits coming in their first two outings of the new campaign.
A strong showing in the Europa League group stages saw Braga qualify from Group G alongside Leicester City at a canter, and Portugal's fourth force have shown they are in a good position to challenge the traditional trio that rules over the Iberian nation's footballing landscape.
After seeing Carvalhal depart in the summer, Rio Ave turned to Mario Silva to try and carry on the good work the 55-year-old started, but his compatriot has had a trickier time.
Vilacondenses were knocked out of the Europa League playoffs by Italian giants AC Milan, and their two league wins to date indicate an immediate return to continental competition is unlikely.
While Rio Ave's defensive record has rightly won many plaudits, with seven goals conceded meaning they have the joint-best record at the back, they are yet to find a balance throughout the side.
Silva's men have found the back of the net on just five occasions, the joint-lowest total in the Primeira Liga. It is, therefore, no surprise that their current three-game winless run in the league has seen them fail to score in each of those clashes.
Braga Primeira Liga form: WWWWWL
Braga form (all competitions): WWLWWW
Rio Ave Primeira Liga form: LWWDLD
Rio Ave form (all competitions): WDWLDW
Portuguese forward Paulinho will be hoping to retain his place in the starting lineup after bagging a hat-trick last time out.
Rio Ave will have to cope without Matheus Reis once again as the Brazilian defender is still suspended by the club after refusing to play against Vitoria de Guimaraes back in September.
Braga possible starting lineup:
Matheus; Sequeira, Carmo, Viana; Galeno, Castro, Elmusrati, Esgaio; Horta, Paulinho, Medeiros
Rio Ave possible starting lineup:
Kieszek; Pinto, Borevkovic, Santos, Amaral; Pele, Augusto; Mane, Geraldes, Lopes; Gelson
We say: Braga 2-0 Rio Ave
The two teams enter Tuesday's game in contrasting form. Braga will have serious ambitions of upsetting the odds and finishing in the top three, while Rio Ave will be hoping to turn their season around and rediscover their goalscoring touch.
A trip to the Estadio Municipal de Braga is not the easiest place to do that though, and Carvalhal will be confident of getting one over his former side.