The Lilywhites' clash with Aston Villa on the same day was called off due to a coronavirus outbreak in their opponents' camp, but Fulham have stepped in to play a game that was originally intended to take place two weeks ago.
In what is perhaps a sign of things to come in the second half of the season, the Premier League acted swiftly to ensure that Tottenham had a game to play on Wednesday after opponents Villa were forced to withdraw.
It may be far from ideal preparation for both managers, but Jose Mourinho will be grateful that his side at least have a game to play and a chance to make it four wins in a row.
Spurs have won their last three without conceding in three different competitions, a run that has seen them reach the final of the EFL Cup, the fourth round of the FA Cup and climb up to fourth in the Premier League.
All focus now is on the top flight, with Tottenham still very much in title contention thanks to a return of 29 points from 16 matches.
That is largely thanks to teams around them also dropping points, having gone four without a league victory prior to the 3-0 win over Leeds United last time out in the competition.
They followed that up with cup wins over Brentford and Marine - Carlos Vinicius scoring a hat-trick in the second of those games in what was a straightforward 5-0 victory against the eighth-tier side.
Fulham were also victorious in their FA Cup third-round tie, albeit after being pushed all the way by West London rivals Queens Park Rangers at Loftus Road.
Scott Parker's men are now unbeaten in five in all competitions, although the other four games in that sequence finished in draws, the most recent being a stalemate with Southampton.
That leaves Fulham in the relegation zone, but they have two games in hand to play on Brighton and Hove Albion directly above them and a three-point margin to gap.
Having made his side far tougher to beat over the past month, the next step for Parker is to start putting some victories on the board.
Tottenham Hotspur Premier League form: WDLLDW
Tottenham Hotspur form (all competitions): LWDWWW
Fulham Premier League form: WLDDDD
Fulham form (all competitions): LDDDDW
The ex-Southampton man has been one of Tottenham's most consistent performers this term and Mourinho is expected to risk him for this visit of Fulham.
As for Fulham, they have no known injury or suspension problems, which is a real rarity for any top-flight clubs in the current climate.
Parker is therefore spoiled for choice, though he is likely to revert back to something close to the same XI that started against Southampton on Boxing Day.
Tottenham Hotspur possible starting lineup:
Lloris; Aurier, Alderweireld, Dier, Reguilon; Winks, Hojbjerg; Bergwijn, Ndombele, Son; Kane
Fulham possible starting lineup:
Areola; Aina, Andersen, Adarabioyo; Cordova-Reid, Lemina, Reed, Anguissa, Robinson; Mitrovic, Lookman
We say: Tottenham Hotspur 3-1 Fulham
Fulham have made themselves tough to beat, last losing a game in any competition on December 5.
They have taken a point off Liverpool in that run, but we can see Tottenham - themselves in good form thanks to three successive wins - prevailing in Wednesday's hastily-arranged match.
Top betting tip
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