Meanwhile, Genoa make the trip to the Mapei Stadium knowing that three points will ensure that they are playing top-flight football next season.
Having previously put together an eight-match unbeaten streak, the 2-0 defeat to Napoli has now extended Sassuolo's winless run to four matches.
Remarkably, Roberto De Zerbi's team had four goals disallowed through VAR, something which should be taken into consideration when making a judgment on the result.
Nevertheless, I Neroverdi will be disappointed that they have not been able to wrap up a minimum of eighth position ahead of welcoming Genoa to their home ground.
While one more win may prove enough to safeguard eighth spot for Sassuolo, another victory for Genoa would mathematically secure their top-flight status for another 10 months.
To their credit, recording nine points from a possible 15 has been required to create some distance between themselves and Lecce, who need wins over Udinese and Parma to have any chance of remaining in the division.
Nevertheless, Davide Nicola will not want to rely on other results, instead demanding that his side hit back from suffering a 3-0 reverse at the hands of Inter Milan.
Having fought hard to gain late wins over Lecce and Sampdoria, succumbing so tamely to the inconsistent top-four outfit would have disappointed Nicola, who will feel like he has done more than enough to be given a chance next season with seven triumphs and five draws coming from 20 matches.
Sassuolo Serie A form: WWDDLL
Genoa Serie A form: LWLWWL
Lasse Schone will almost certainly be brought back into Genoa's midfield after beginning the defeat to Inter on the substitutes' bench.
Sassuolo will be able to call upon midfielder Mehdi Bourabia after being sidelined for the setback at Napoli due to a ban.
Having missed the last game with a muscular injury, Boga may be deemed fit enough to be named among the replacements.
Sassuolo possible starting lineup:
Consigli; Muldur, Santos, Ferrari, Rogerio; Bourabia, Locatelli; Berardi, Djuricic, Traore; Caputo
Genoa possible starting lineup:
Perin; Goldaniga, Romero, Zapata; Ankersen, Behrami, Schone, Jagiello, Criscito; Pinamonti, Pandev
We say: Sassuolo 2-1 Genoa
Despite their contrasting fortunes this season, this has the makings of being a closely-fought battle. However, we feel that Sassuolo will just about have enough to see off opponents who may be torn between trying to gain a point and pushing for all three.