Ajax vs. Rangers (Wednesday, 5.45pm)
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Scottish giants Rangers travel to Amsterdam to face Eredivisie champions Ajax on Wednesday night in their opening Champions League group-stage match of the 2022-23 campaign.
While the hosts will be seeking to bounce back from a heavy Old Firm derby defeat last weekend, the hosts are looking to claim their sixth successive victory in all competitions.
We say: Ajax 2-1 Rangers
Considering their bright start to the new season and the advantage of playing in front of their own fans, Ajax will be regarded as the favourites for Wednesday's contest, although Rangers tend to thrive on the European stage and should not be underestimated.
The Gers will be desperate to respond with a strong performance after last weekend's defeat, but we can see the hosts kick-starting their group-stage campaign with maximum points.
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Frankfurt vs. Sporting Lisbon (Wednesday, 5.45pm)
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Europa League winners Eintracht Frankfurt begin their 2022-23 Champions League campaign with a showdown against Sporting Lisbon on Wednesday evening.
However, both clubs head into this contest having endured a mixed start to their domestic schedules, increasing the pressure ahead of the game at Deutsche Bank Park.
We say: Eintracht Frankfurt 2-1 Sporting Lisbon
With both teams having prevailed in their latest league fixture, there will be a feeling of optimism heading into this contest. However, while we expect Sporting to get on the scoresheet in Germany, we are backing Frankfurt to make their home advantage count in what should be an entertaining tussle.
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Napoli vs. Liverpool (Wednesday, 8.00pm)
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Liverpool will be hoping that their recent domestic misfortune does not carry over onto the European stage when Napoli play host to the Reds in their opening Champions League Group A match on Wednesday.
The two sides renew hostilities at the Stadio Diego Armando Maradona prior to also meeting Ajax and Rangers in Group A, and the Partenopei have enjoyed a far better opening to their league season.
We say: Napoli 2-1 Liverpool
While the possible introduction of Arthur will only benefit Liverpool on the progressive front, Klopp's attackers have struggled to convince early doors and must now attempt what no Liverpool team has done before - score an away goal against Napoli.
Spalletti's side are far from watertight at the back following the sale of Kalidou Koulibaly, but the Serie A leaders can feel confident about winning the midfield battle this week, and we have faith in the Partenopei to extend their unbeaten Champions League home run at the expense of Liverpool's golden away streak.
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> How Liverpool could line up against Napoli
> Liverpool injury, suspension list vs. Napoli
Atletico vs. Porto (Wednesday, 8.00pm)
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Atletico Madrid will be looking to get their Champions League group-stage campaign off to the best possible start when they welcome Porto to Wanda Metropolitano on Wednesday night.
Diego Simeone's side will enter the match off the back of a 1-1 draw with Real Sociedad in La Liga on Saturday, while Porto were 2-0 winners over Gil Vicente in Primeira Liga last time out.
We say: Atletico Madrid 1-1 Porto
Both of these sides will fancy their chances of winning on Wednesday night, but it is very difficult to back Atletico to lose at Wanda Metropolitano in any game against any opposition. It would not be a surprise to see a home victory, but we have a feeling that Porto could pick up a welcome point here.
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Brugge vs. B. Leverkusen (Wednesday, 8.00pm)
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Club Brugge play host to Bayer Leverkusen on Wednesday evening looking to take their domestic form into the Champions League.
The Belgian outfit have 16 points from their opening seven top-flight fixtures, while Leverkusen have already posted four defeats at the start of their Bundesliga campaign.
We say: Club Brugge 1-2 Bayer Leverkusen
There is an argument that Brugge are the favourites heading into this contest, particularly with home advantage in their favour. However, things must click into gear for Leverkusen at some stage, and we feel that they will do just enough to earn all three points on Wednesday.
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Barcelona vs. Plzen (Wednesday, 8.00pm)
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Barcelona will be aiming to get their Champions League Group C campaign off to the best possible start when they welcome Viktoria Plzen to Camp Nou on Wednesday night.
The Catalan outfit will enter the match off the back of a 3-0 win over Sevilla in La Liga on Saturday, while Plzen recorded a 1-0 victory over Slovan Liberec in Czech Liga in their last game.
We say: Barcelona 3-0 Viktoria Plzen
Barcelona have won their last three matches 4-1, 4-0 and 3-0, and we are finding it very difficult to back anything other than a strong home victory here. Plzen could have a tough time in the section, and we are expecting Xavi's side to start their 2022-23 European campaign with a comfortable success.
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> How Barcelona could line up against Viktoria Plzen
> Barcelona injury, suspension list vs. Viktoria Plzen
Inter Milan vs. Bayern (Wednesday, 8.00pm)
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Kicking off an intense autumn of Champions League action, Inter Milan host German giants Bayern Munich at San Siro on Wednesday.
The Group C rivals clash on the opening matchday, with Inter having suffered a galling defeat in the Milan Derby while their visitors were held for a second successive Bundesliga game.
We say: Inter Milan 1-2 Bayern Munich
Despite a couple of blips, Bayern have been both relentless and ruthless in the early stages of the new season, and they will find an Inter side nursing their wounds on Wednesday. With a creaking defence, the Nerazzurri are set to be unpicked more than once by Die Roten.
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Spurs vs. Marseille (Wednesday, 8.00pm)
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Tottenham Hotspur's return to the promised land of the Champions League commences with Wednesday's Group D fixture against Ligue 1 giants Marseille.
Eintracht Frankfurt and Sporting Lisbon are also lying in wait for Antonio Conte's side, who can take nothing for granted in such a challenging European group.
We say: Tottenham Hotspur 2-2 Marseille
One look at the Marseille defence does not inspire too much confidence, and an in-form Kane alongside a bright Richarlison can expect joy in front of goal if Conte's side can win what should be an entertaining midfield scrap.
It is impossible to ignore Les Olympiens' magnificent start to the new campaign, though, and with Tottenham likely to be a little rusty on the biggest European stage, Tudor's side are more than capable of snatching a point here.
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