Meanwhile, Villa travel to Old Trafford knowing that victory will move them to within one point of their second-placed opponents in the standings.
Man United have made a habit of prevailing in high-scoring matches this season, particularly away from home when they have often conceded an early goal.
However, Ole Gunnar Solskjaer would have taken a great deal of satisfaction from a scrappy 1-0 victory over Wolverhampton Wanderers on Tuesday night, a result earned through a deflected 93rd-minute winner from Marcus Rashford.
The result was harsh on a much-changed visitors who inevitably tired in their second game in 48 hours, but Solskjaer will prefer to focus on the perseverance of his players in a match where they were nullified effectively for the most part.
Rashford's decisive strike is currently the difference between fourth and second, and a second successive win over Midlands opposition will put further distance between themselves and the most improved side in the division.
While Solskjaer and his United squad may not regard Villa as long-term rivals in the hunt for the Champions League places, they will be aware that defeat on Friday evening would leave Dean Smith's side in a strong position.
Sitting four points adrift of second position with a game in hand, Smith deserves the widespread praise that he has received for transforming Villa from a relegation-threatened side into a club which now have genuine ambitions to finish in the top four.
However, Villa's recent performances have come without any added pressure on their shoulders, and it remains to be seen how they will cope with expectations rising significantly among their fanbase.
With 24 matches still to play, Smith will stress that his players cannot afford to get ahead of themselves when consistency could be a deciding factor come the end of the season.
Nevertheless, Villa were outstanding during the second half of their meeting with Chelsea on Monday, and having an extra day's rest can only benefit them ahead of a fixture of this magnitude.
Manchester United Premier League form: WDWWDW
Manchester United form (all competitions): DWWWDW
Aston Villa Premier League form: LWDWWD
Manchester United possible starting lineup:
De Gea; Wan-Bissaka, Bailly, Maguire, Shaw; McTominay, Fred; Greenwood, Fernandes, Rashford; Martial
Aston Villa possible starting lineup:
Martinez; Cash, Hause, Mings, Targett; Luiz, McGinn; El Ghazi, Barkley, Grealish; Watkins
We say: Manchester United 2-1 Aston Villa
Having performed so impressively during the second half at Chelsea, Villa will fancy their chances of taking more points off their rivals for a European place. However, having more options to rotate will help Solskjaer, and the home side should have enough quality to outlast their in-form opponents.
Top betting tip
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