Roma are already assured of their fifth-placed finish and, like their opponents, have little to play for this weekend.
While Juventus have managed to secure an unprecedented ninth straight title in the Italian top flight, the Old Lady have reclaimed their crown in less-than-convincing fashion this time around.
Maurizio Sarri's men followed up their title-clinching victory over Sampdoria with a dismal 2-0 defeat to 13th-placed Cagliari on Wednesday, as first-half strikes from Luca Gagliano and Giovanni Simeone put Juve to the sword early on.
The result means that the Serie A champions have now only tasted victory twice in their last seven outings, but with the title already in the bag, there is little pressure on Sarri's men for the visit of Roma.
The Old Lady will soon turn their attention to their quest for Champions League glory when they welcome Lyon to Turin for the second leg of their last-16 tie, although Juventus will need to overturn a 1-0 deficit from the first leg.
For now, though, the Old Lady must focus on the task at hand against Roma as they look to record their 40th Serie A home game in a row without defeat - a run stretching all the way back to May 2018.
Meanwhile, Roma got the job done over a struggling Torino outfit in midweek as they secured a top-five finish for the 2019-20 campaign.
Paulo Fonseca's men came out on the correct end of the scoreline in a five-goal thriller with Il Toro, with goals from Edin Dzeko, Chris Smalling and Arsenal-linked Amadou Diawara propelling Roma to their third victory in succession.
I Giallorossi are finishing the season strongly and now boast a seven-game unbeaten run in the Italian top flight - a run of form which could have seen them push for a Champions League berth earlier in the campaign.
Nevertheless, Roma will have to make do with another campaign in the Europa League unless they can go all the way in this season's tournament, with a trip to Sevilla in the last 16 on the agenda for Fonseca's side in August.
Juventus and Roma have already met twice this season, and it was the Old Lady who took the spoils on both occasions with a 2-1 league victory preceding a 3-1 triumph in the Coppa Italia quarter finals.
Juventus Serie A form: DDWLWL
Roma Serie A form: WWDWWW
Sarri bemoaned a hectic fixture schedule following his side's defeat to Cagliari, and the Juventus manager has hinted that he may give chances to several up-and-coming players for the visit of Roma.
As for Fonseca's side, Lorenzo Pellegrini has undergone successful surgery on a fractured nose, but Saturday's game is expected to be too soon for the midfielder.
Juventus possible starting lineup:
Buffon; Danilo, Demiral, Rugani, Matuidi; Peeters, Rabiot, Ramsey; Bernardeschi, Olivieri, Ronaldo
Roma possible starting lineup:
Lopez; Smalling, Ibanez, Kolarov; Zappacosta, Veretout, Diawara, Spinazzola; Zaniolo, Mkhitaryan; Kalinic
We say: Juventus 1-1 Roma
Juventus are expected to field a heavily weakened-team with the Champions League in mind, and Roma also have European aspirations of their own heading into August. As a result, we are expecting the two sides to exercise caution and play out a draw in the final weekend of the season.