From Mainz's perspective, they will look to enjoy the final game of the season having successfully avoided relegation with back-to-back wins.
While the race for the Champions League has been nip and tuck in recent weeks, Leverkusen will be bitterly disappointed to head into their final game with their fate not in their own hands.
Collecting just four points from a possible 12 has handed the initiative to Borussia Monchengladbach, who will finish in the top four should they defeat Hertha Berlin.
With Monchengladbach also holding a significantly better goal difference, Leverkusen will be aware that only defeat for their closest rivals will allow them to claim a place at European football's top table.
Although they still have the backup of the Europa League, Peter Bosz is aware that players, including Kai Havertz, may need to be sold if they miss out on the financial benefits of playing in the Champions League.
Should that be the case, the playmaker will want to go out on a high having produced one of his most ineffective performances of the season against Hertha last Saturday.
One factor in Leverkusen's favour is Mainz's recent revival, one which has guaranteed their top-flight status for another 12 months.
Mainz failed to win any of their first four games after the resumption, resulting in the club moving closer to the bottom three at a time when Werder Bremen were finding some form.
However, excellent away triumphs at Eintracht Frankfurt and Borussia Dortmund respectively put the club on the brink of survival, before the job was completed with a 3-1 success against Bremen last weekend.
Although Achim Beierlorzer will naturally want to finish as high in the standings as possible, it would come as no great surprise if the level of his players dropped with much less at stake.
If Mainz were able to end the season with four wins from five games, they may still be able to finish in 11th place.
Bayer Leverkusen Bundesliga form: LWLDWL
Mainz 05 Bundesliga form: DLWLWW
While Bosz could be tempted to make a number of changes to his starting lineup, he will likely rely on experience over youth.
Mainz boss Beierlorzer has insisted that he will select his best possible side for the game at the BayArena.
Bayer Leverkusen starting lineup:
Hradecky; Dragovic, Tah, Tapsoba, Wendell; Baumgartlinger, Dmeribay; Diaby, Havertz, Bailey; Volland
Mainz 05 possible starting lineup:
Muller; Baku, Juste, Niakhate, Brosinski; Latza, Kunde; Onisiwo, Oztunali, Quaison; Mateta
We say: Bayer Leverkusen 3-1 Mainz 05
Given their respective paths in recent weeks, we can only back Leverkusen to prevail in this contest. Mainz have been playing high-stakes fixtures for weeks, and having finally achieved their goal may ultimately lead to a lower level of performance this weekend.