The Red Bulls won their last four away games last season and went seven without defeat, but Leverkusen have been solid on home soil in 2020, winning six out of eight at BayArena.
That question was pretty emphatically answered on the opening weekend as last term's Champions League semi-finalists made light work of Mainz 05 in a 3-1 home win.
The Red Bulls have now lost just one of their last 16 Bundesliga matches - 2-0 versus Borussia Dortmund towards the end of last season - and boast that impressive away return.
This trip to BayArena will be a difficult one for Nagelsmann's charges, however, as Leverkusen have only lost their first home match of a campaign once before.
Die Werkself's 2020-21 campaign got off to a bit of a slow start last weekend, though, having been held to a goalless draw at Wolfsburg.
Bayer did nab Schick from Roma during the summer, however, and there will be plenty of focus on him this weekend against the side he represented last season.
Going one better than last term's fifth-placed finish will be the aim for Bosz, but his side will have to improve on last week's showing if they are to achieve that.
This is not a fixture Leverkusen tend to do well in, either, winning just one of their last eight top-flight encounters with Leipzig - 4-1 at BayArena in April 2018.
In fact, Leverkusen have won none of their four Bundesliga home games against Leipzig - their worst-such record against any side in the division.
Bayer Leverkusen Bundesliga form: D
Bayer Leverkusen form (all competitions): WD
RB Leipzig Bundesliga form: W
RB Leipzig form (all competitions): WW
Schick, who was given a 30-minute runout from the bench last weekend but could not find a breakthrough goal, will be pushing for a start against his former side.
Should that be the case, Argentina international Lucas Alario will be the player to make way for the home side.
As for Leipzig, they secured the services of Norwegian striker Alexander Sorloth earlier this week and could hand him his Bundesliga debut at BayArena.
Poulsen and Forsberg have each scored three Bundesliga goals against Leverkusen, which is more than any other players in this fixture.
Bayer Leverkusen possible starting lineup:
Hradecky; L.Bender, S.Bender, Tapsoba, Sinkgraven; Wirtz, Aranguiz, Demirbay; Bellarabi, Schick, Diaby
RB Leipzig possible starting lineup:
Gulacsi; Klostermann, Upamecano, Halstenberg; Haidara, Sabitzer, Kampl, Angelino; Olmo, Forsberg; Poulsen
We say: Bayer Leverkusen 1-2 RB Leipzig
Both teams are having to cope with the loss of key men. Leipzig hit the ground running with a routine home win on the opening weekend, whereas Leverkusen were held by Wolfsburg, and we can see the visitors prevailing in this one.