Barca's lead at the top of the table currently stands at three points, but Real Madrid will have the chance to move level on points with the reigning champions when they face Real Sociedad on Sunday night.
Quique Setien's side have been in good form since returning to action on June 13, beating Mallorca and Leganes in back-to-back games before claiming a point at the Estadio Ramon last time out.
The games are coming thick and fast for Barca as they will face Athletic, Celta Vigo and Atletico Madrid before the end of the month, and it does not appear that Real Madrid's challenge is going to falter.
Barca have the best home record in La Liga this term, winning 14 of their 15 matches, remaining unbeaten in the process, and there is no question that they will be the favourites to triumph on Tuesday night.
Athletic recorded a 1-0 victory in the reverse match at San Mames earlier this season, though, and also picked up a point at Camp Nou last term. In fact, the Basque outfit are unbeaten in their last three league encounters with Barca, having also drawn their home league match with the Catalan giants during the 2018-19 season.
The visitors have picked up five points from their three matches since returning to action on June 14, following draws against Atletico Madrid and Eibar with a 1-0 success over Real Betis on Saturday night.
Athletic are currently 10 points off the top four but sit just six points behind fifth-placed Getafe at this stage, and there is no question that the club will have their eyes on a potential European spot.
The Basque outfit have struggled on their travels this season, though, picking up just two victories from their 15 away fixtures, which is a concern as they head to the side with the best home record in the division.
Barcelona La Liga form: WLWWWD
Barcelona form (all competitions): DLWWWD
Athletic La Liga form: LWWDDW
Athletic form (all competitions): WLWDDW
Frenkie de Jong should shake off a calf injury to start, though, and Setien is expected to shuffle his pack from the side that started Friday's clash at the Estadio Ramon.
Luis Suarez played the full 90 minutes against Sevilla, but the Uruguay international could start on the bench against Athletic, having been out for an extended period following knee surgery.
The bulk of the XI that started at the weekend are expected to once again take to the field, although Mikel Vesga is pushing for a spot in the middle of the park.
Barcelona possible starting lineup:
Ter Stegen; Semedo, Pique, Lenglet, Alba; Arthur, Busquets, De Jong; Griezmann, Messi, Fati
Athletic possible starting lineup:
Simon; Capa, Nunez, Martinez, Balenziaga; D Garcia, Vesga; Cordoba, Muniain, Williams; R Garcia
We say: Barcelona 2-1 Athletic Bilbao
Athletic are certainly capable of making it a very uncomfortable 90 minutes for Barca, who could be level on points with Real Madrid by the time that they take to the field. The Spanish champions will be determined to return to winning ways following Friday's draw with Sevilla, though, and we fancy the home side to pick up an important three points at Camp Nou.