Sitting in eighth and ninth position respectively, each club is under pressure to get another win on the board as they bid to qualify for next season's Europa League.
Although Valencia sit just three points behind sixth place, Albert Celades will be aware that he is fighting to keep his job at the Mestalla in the long term.
Just two victories have been recorded from their last 10 matches, and it leaves Los Che with little momentum heading into their closing half-a-dozen outings.
Back-to-back defeats without scoring a goal have been posted on the road against Eibar and Villarreal, results which have realistically left the club out of the running for a Champions League spot.
Nevertheless, club officials will be eager to earn qualification for the Europa League, aware that any financial benefits over the next 12 months could prove crucial if they wish to remain as one of the nation's top clubs.
Despite holding a slender advantage in the table over their next opponents, there is little doubting that Athletic head into this contest as the favourites.
Eight points have been recorded from five games since the resumption, with their only defeat coming at the hands of Barcelona at Camp Nou.
Wins were registered against Real Betis and Mallorca either side of that blip, ensuring that Athletic remain as the form team of the clubs battling it out for sixth.
Although no players are necessarily standing out in the final third, just five goals have been conceded in as many games, an impressive return when also taking into account that they returned to action with a clash against Atletico Madrid.
However, with Real Madrid and Sevilla to follow their clash with Valencia, Gaizka Garitano knows that it is the wrong time to suffer a 10th league defeat of the season.
Valencia La Liga form: DDLWLL
Athletic Bilbao La Liga form: WDDWLW
Eliaquim Mangala is back in contention after serving a one-match ban.
Barring any late fitness issues, Garitano is unlikely to make any alterations to his Athletic starting lineup.
Iker Muniain may feel that his place is under threat after a number of ineffective showings in quick succession.
Valencia possible starting lineup:
Cillessen; Florenzi; Paulista, Mangala, Costa; Torres, Kondogbia, Parejo, Guedes; Gameiro, Gomez
Athletic Bilbao possible starting lineup:
Simon; Capa, Alvarez, Martinez, Yuri; Lopez, D.Garcia; Williams, Sancet, Muniain; R.Garcia
We say: Valencia 1-2 Athletic Bilbao
Despite having home advantage, we make Valencia the underdogs heading into this contest. Athletic are beginning to put together some momentum, and another victory here will leave the teams above them looking over their shoulders.