Antonio Conte will take charge of his first home game as Tottenham Hotspur boss as Leeds United visit North London on Sunday.
Title contenders Manchester City also take on Everton earlier in the day, while Inter Milan host Napoli in Serie A's game of the day.
The likes of Real Madrid, Ajax and Rangers are also in action, while one of the biggest games of the Turkish calendar - Galatasaray vs. Fenerbahce - takes place.
Below is Sports Mole's selection of predictions and previews for Sunday and Monday.
