A crucial game on the battle for a top-four finish in the Premier League headlines Saturday's action as Arsenal host Manchester United.
Fellow top-four hopefuls Tottenham Hotspur are also in action, while Manchester City will be attempting to move clear of Liverpool when they host Watford.
Elsewhere, Bayern Munich could win the title with victory in Der Klassiker against Borussia Dortmund, while Paris Saint-Germain could clinch the Ligue 1 crown too.
Below is Sports Mole's selection of predictions and previews for today's and tomorrow's fixtures.