As for Northern Ireland, Ian Baraclough's side realistically need all three points if they are to retain hope of avoiding relegation to League C.
Despite a difficult opening as manager of Northern Ireland, Baraclough would have had high hopes that his under-performing side could find a spark against Slovakia in their Euro 2020 playoff tie on Thursday evening.
Although the Green and White Army rallied during the closing stages of the contest in Belfast, their efforts were undone by a lack of a ruthless streak in the final third.
That is something which has been present in this team for some time, and Michal Duris's goal in extra time has left Baraclough and this squad facing an uphill task to remain among a group of mid-range nations.
Already sitting three points adrift at the bottom of League B Group 1, Northern Ireland need a positive result in Vienna to ensure that they have something to play for when hosting Romania next week.
If Wednesday's opponents succumb to Norway at the weekend, Baraclough's side will earn themselves a lifeline, arguably on both a short and long-term basis, if they win at Windsor Park.
Nevertheless, their priority must be on trying to upstage an Austria side who have responded brilliantly to their shock defeat at home to Romania in September.
Franco Foda has watched Unsere Burschen register four victories in succession, as well as going almost 300 minutes without conceding a goal.
A home fixture against goal-shy opponents is the perfect encounter as they bid to move closer to promotion, but Foda will also have reservations about their own efforts in the final third.
All but one of their last eight goals have been scored in the second half, a statistic which will need to change ahead of their appearance at Euro 2020 next year.
Austria Nations League form: WLWW
Austria form (all competitions): WLWWWW
Northern Ireland Nations League form: DLLL
Northern Ireland form (all competitions): DLDLLL
After going to extra time on Thursday night, Baraclough is likely to make a number of changes to his side.
Marcel Sabitzer may be recalled to the Austria XI after missing out against Romania last month.
Forward Marko Arnautovic is expected to be named among the replacements.
Austria possible starting lineup:
Pervan; Lainer, Dragovic, Hinteregger, Alaba; Sabitzer, Ilsanker, Baumgartlinger, Baumgartner; Gregoritsch, Schlager
Northern Ireland possible starting lineup:
Peacock-Farrell; Dallas, Cathcart, Evans, Lewis; Whyte, McNair, Galbraith,Jones; Boyce, Magennis
We say: Austria 2-0 Northern Ireland
On the back of Thursday night's disappointment, this is an unwanted test for Northern Ireland. While Baraclough's side will go out with the best of intentions, it is difficult to see them making much of an impact against their in-form and motivated hosts.