Liverpool have confirmed that Virgil van Dijk, Fabinho and Curtis Jones have all returned "suspected positive tests" for coronavirus.
The trio will all miss Thursday night's Premier League clash with Newcastle United as a result, having entered isolation.
The news is the latest case of a coronavirus outbreak within a club, with the Premier League having had to postpone six games on Thursday and now nine overall.
Liverpool have so far not had one of their matches postponed, but they have now confirmed their first coronavirus cases of the current wave.
"Fabinho, Curtis Jones and Virgil van Dijk will miss tonight's Premier League fixture against Newcastle United after registering suspected positive tests for COVID-19," read a statement on the club's official website.
"The three players are now isolating. As a result, the entire Reds' set-up, including all players and staff, were tested for COVID-19 again today with no further positive cases being detected."
Liverpool could move back to within one point of the top of the Premier League table with victory over Newcastle this evening.
