Thiago Silva and Raheem Sterling both return to the Chelsea XI for Saturday's Premier League fixture against Sheffield United.
On the back of last week's 2-0 defeat at Everton, head coach Mauricio Pochettino was always likely to make alterations to his starting lineup.
However, injuries to Robert Sanchez, Reece James and Marc Cucurella means that a wide array of changes have occurred to the Blues side for the meeting with the Blades.
As expected, goalkeeper Djordje Petrovic replaces Sanchez between the sticks, with Silva and Levi Colwill returning to the team for James and Cucurella.
Further forward, Enzo Fernandez and Armando Broja have both been dropped to the substitutes' bench, with Sterling and Nicolas Jackson joining Cole Palmer and Mykhaylo Mudryk in the final third.
Christopher Nkunku is also named in a Premier League squad for the first time, with the France international beginning on the substitutes' bench after recovering from a knee injury.
Meanwhile, Chris Wilder has made two alterations to the Sheffield United team that started the 1-0 victory over Brentford.
Max Lowe and Oli McBurnie - who is returning from suspension - are included ahead of Jack Robinson and William Osula.
Chelsea: Petrovic; Disasi, Silva, Badiashile, Colwill; Gallagher, Caicedo; Sterling, Palmer, Mudryk; Jackson
Subs: Bergstrom, Bettinelli, Gilchrist, Gusto, Maatsen, Fernandez, Matos, Nkunku, Broja
Sheffield United: Foderingham; Bogle, Trusty, Ahmedhodzic, Lowe; Souza; McAtee, Hamer, Brooks, Archer; McBurnie
Subs: Davies, Osborn, Baldock, Traore, Osula, Thomas, Larouci, Slimane, Norwood
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