Jurgen Klopp's side currently sit a point clear at the top of Group C, with at least one of Napoli and Paris Saint-Germain - who sit second and third respectively - guaranteed to drop more points when they face each other.
Liverpool won the reverse fixture 4-0 a fortnight ago but will be expecting a more difficult test in Belgrade, where Napoli could only manage a goalless draw on matchday one.
Here, Sports Mole looks at how Liverpool could line up for the game.
Captain Jordan Henderson is expected to return to training prior to Tuesday's match, but he may not be thrown straight back into the starting lineup by Klopp.
Naby Keita is also nearing a return from his own hamstring problem and should be back in training next week too, although the trip to Belgrade is likely to come too soon for him.
Klopp therefore has a decision to make in midfield after Fabinho's performance in Saturday's draw with Arsenal was heavily scrutinised, and either Adam Lallana or Xherdan Shaqiri should benefit from that.
Dejan Lovren missed the Arsenal game with a muscle injury and remains a doubt for this match, meaning that the back four is likely to be unchanged with Joe Gomez partnering Virgil van Dijk at the heart of the defence.