The hosts come into this match with just a point to their name at the halfway stage of the group and knowing that defeat could see them eliminated from the competition should Napoli also beat Paris Saint-Germain.
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Group C is very finely poised at the halfway stage with only two points separating the top three teams, while bottom-placed Red Star know that they could be eliminated from the competition tonight should results go against them. Both teams have it all to play for, so we should be in for an intriguing encounter two weeks on from the one-sided contest at Anfield.
Let's start with a look at the team news...
There had been rumours in the buildup to this match that Firmino may be taken out of the team having struggled for goals this season, but in the Champions League he has been involved in 19 since the start of last season - more than any other player in the competition during that time.
The Brazilian has scored 12 and assisted another seven of those in that time, so it is still a slight surprise to see him miss out.
The England striker's inclusion is one of three changes made by Klopp from the weekend draw with Arsenal, as Joel Matip is handed a rare start in place of Gomez and Adam Lallana replaces Fabinho.
Lallana could switch to that number 10 role, of course, with Sturridge up front and Salah and Mane continuing their usual positions out wide for the visitors tonight.
Salah has now got four in his last four games for the club, while Mane has now scored 11 goals in his last 12 Champions League outings.
the likes of Gomez and Fabinho - both of whom featured against Arsenal - are also amongst the subs, but there is no Dejan Lovren despite the centre-back being included in the travelling party after missing the weekend through injury.
Babic, Gobeljic, Jovicic, Edecilio and Richmond Boakye are the players to make way, with the latter missing from the squad entirely despite having scored five goals in just four league appearances this season.
Captain Vujadin Savic also returns at the heart of the defence for his first European appearance since being taken off at half time of the PSG drubbing. Watford fans may remember Savic from a brief spell at Vicarage Road earlier in his career.
Indeed, Ben netted nine times in his first 11 games for the club this term, although his strike against Proleter on Saturday was the first time he has scored since September 2.
The Belgrade outfit are appearing in the group stages of the Champions League for the very first time - finally qualifying after six failed attempts in the past - but defeat tonight could see them eliminated with two games of the group stages remaining should Napoli also beat PSG in Naples.
It is no surprise, then, to see the tournament debutants sitting bottom of Group C with just one point to their names - although manager Vladan Milojevic will not want his side to go down without a fight.
As a result of those two games, the Serbian outfit have now conceded the most goals (10), shots (75) and shots on target (36) of any team in the Champions League this season. They also have the joint-worst attacking record, having scored only once.
The fans create a hostile environment in the stadium and their only home game of the group stages so far saw them hold Napoli - who beat Liverpool - to a goalless draw on matchday one.
Even so, Red Star have conceded just five goals in those 14 games, keeping nine clean sheets in the process and never shipping more than one goal in a game - a stark contrast to their last two away games.
It is a different level in European competition, though - particularly the Champions League. Despite coming through qualifying, Red Star have failed to win inside normal time in any of their last seven outings across all competitions stretching back to August 1, when they overcame Lithuanian side Suduva in the second qualifying round.
The reigning champions have taken 43 points from the first 45 on offer in the Super Liga to build a nine-point gap after only 15 games, while they are now unbeaten in their last 41 league games and have won a staggering 24 of their last 25.
Napoli's draw here gives an example of how difficult this test could be for them, but at the same time any dropped points could prove very costly in such a competitive group and tonight is a huge chance for Liverpool to move to the brink of qualification for the last 16.
Indeed, the double-headers against Red Star could prove to be decisive in the group considering the strength of the other three teams, so with Napoli having drawn here a victory for Liverpool tonight would give them the edge over the Serie A outfit.
PSG's late equaliser against Napoli on matchday three worked out perfectly for Liverpool as their 4-0 win against Red Star took them top of the group, and a draw in Naples tonight would also be a very welcome result for Klopp's side.
Indeed, it was their goalscoring feats which took them all the way to the final last season, and since the beginning of the 2017-18 campaign no club can match Liverpool's tally of 48 goals scored in just 16 games.
Liverpool have now won just five of their last 20 European away games, drawing eight of those and losing seven, including both of their last two.
Liverpool are also still unbeaten in the Premier League this season, with Saturday's draw away to Arsenal extending their run to 11 games from the beginning of the campaign - just the second time they have managed that in the Premier League era.
Liverpool can perhaps fell a little hard done by to only be third considering it is unprecedented for three teams to still be unbeaten at this stage of a Premier League season, but they will still be satisfied with their start to the campaign.
This is a difficult one to call as we try to weigh up the ease with which Liverpool won at Anfield against the home advantage for Red Star. The visitors should still have enough to come away with the win, though, and a hostile away environment will not be anything new for this players.
SPORTS MOLE SAYS: Red Star 0-2 Liverpool
It was also Liverpool's first ever victory against Red Star, but they were completely dominant as the front three all got on the scoresheet in a 4-0 drubbing - in addition to Mane missing a penalty.
Liverpool have only visited Belgrade on one previous occasion, then, while their initial meeting at Anfield saw the Reds fall to their first ever home defeat in Europe; the second did not follow for another 18 years.
Red Star had previously been unbeaten in their first seven home games against English teams, including five successive wins prior to the visit of Bolton. How times change, hey Bolton fans?
RED STAR STARTING XI: Borjan; Stojkovic, Savic, Degenek, Rodic; Jovancic, Krsticic, Srnic, Marin, Ben; Pavkov
LIVERPOOL STARTING XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Wijnaldum, Milner; Lallana, Salah, Mane; Sturridge
4️⃣ Goals— Liverpool FC (@LFC) November 6, 2018
🔝 Group C
Same again Reds. 💪 pic.twitter.com/QxP3NEIGV9
Mane's low ball from the right is meant for Robertson, but his attempted shot only bobbles away to Sturridge. It is bouncing awkwardly, but Sturridge still have the goal gaping in front of him and he really should score!
A corner is swung into the box and Pavkov produces a towering header, nodding his finish down past Alisson and in!
Wijnaldum is shrugged off in his efforts to stop Pavkov, who then unleashes a thunderous 25-yard effort into the corner. The defence should have closed him down quicker, and questions can perhaps be asked of Alisson too.
2 - Liverpool have conceded more than once in the first half of a Champions League game for the first time since October 2014 (0-3 defeat v Real Madrid). Rustled. pic.twitter.com/Qz8lq4h6AC— OptaJoe (@OptaJoe) November 6, 2018
It has been a really poor performance from Liverpool so far and they have been punished for some uncharacteristic errors. Red Star have taken full advantage in front of a raucous home crowd.
Pavkov was allowed to rise almost unchallenged and made no mistake with his finish for his first ever European goal - but it would not be his last of the night.
It was a very avoidable goal for Liverpool, though, with Milner initially giving the ball away before Wijnaldum was shrugged off and the defenders allowed Pavkov far too much space to get his shot away. Alisson could perhaps have also done better, although there were plenty of mistakes prior to that.
Defeat tonight could prove very costly with Napoli and PSG still to come in this season's competition.
Jurgen Klopp's side were poor on the night and could not find a way through despite dominating the second half, with Red Star defending the 2-0 lead which Liverpool's mistakes - and a couple of good finishes from Milan Pavkov - had gifted them.
It is a result which blows Group C wide open, and it will be all eyes on Naples now.
Thank you very much for joining Sports Mole for tonight's Champions League clash as Red Star stun Liverpool to leave Group C wide open. I will leave you with our match report, and be sure to stick around for reaction too.
From me, though, it is goodbye for now!