Low was forced to play a weakened side in the 1-0 friendly win over Czech Republic on Wednesday, with several players unavailable for selection through fears of fatigue.
Benfica striker Luca Waldschmidt scored his second goal for his country after notching in another friendly against Turkey last month, with a back three of Jonathan Tah, Robin Koch and Antonio Rudiger keeping their opponents at arm's length.
The likes of Ginter, Goretzka, Timo Werner, Serge Gnabry and Toni Kroos should be available for selection again in the upcoming Nations League fixtures, bolstering Low's options and confidence of topping the group.
The Germans have never really got going in competitive matches of late, with last month's win over Ukraine their only win in the group, but they do remain unbeaten and two wins will see them finish first.
Ukraine have been managed by their record goalscorer and legendary figure Andriy Shevchenko since July 2016, with the former AC Milan and Chelsea striker leading his nation to next summer's European Championships after impressively finishing ahead of Portugal and Serbia in qualifying.
For Ukraine to have a genuine chance of topping a Nations League group which contains recent World Cup winners Spain and Germany with only two games remaining is a tremendous feat, too. Should they manage to record a surprise result in Germany, they will travel to Switzerland on Tuesday with genuine hope of doing so.
Shevchenko's side were far from their best in the 2-0 friendly defeat to Poland on Wednesday, but the 44-year-old will hope his players keep in mind last month's 1-0 victory over Spain more than a game which ultimately did not mean anything.
He will certainly be hoping West Ham United forward Andriy Yarmolenko can rediscover some form having failed to score in his last four internationals.
Germany Nations League form: DDWD
Germany form (all competitions): DDDWDW
Ukraine Nations League form: WLLW
Ukraine form (all competitions): WLLLWL
Goalkeeper Oliver Baumann was denied a chance of earning his first senior international cap against Czech Republic having left the Germany squad as a precautionary measure following his club Hoffenheim picking up several coronavirus cases.
Central defender Niklas Sule has joined up with the squad having served his self-isolation period after testing positive for coronavirus, while the contingent of Champions League players who were rested in Wednesday's friendly should return to action against Ukraine.
Germany possible starting lineup:
Neuer; Ginter, Sule, Rudiger, Schulz; Goretzka, Kroos, Gundogan; Sane, Werner, Gnabry
Ukraine possible starting lineup:
Lunin; Konoplya, Kryvtsov, Matviyenko, Sobol; Makarenko, Zinchenko, Malinovskyi; Yarmolenko, Yaremchuk, Zubkov
We say: Germany 2-0 Ukraine
We expect Ukraine to battle hard as they so frequently do under Shevchenko, but ultimately Germany should have too much firepower for their opponents in order to set up a salivating table-topping clash against Spain on Tuesday.