Spurs beat Crystal Palace in the first official match at the £850m venue and followed that up with a 1-0 win over Manchester City in the first leg of their Champions League quarter-final tie in midweek.
The move into their new stadium arguably came at the perfect time for Tottenham, who had won just one of their six matches immediately before the Palace and Man City games.
A change of surroundings has paid off as Spurs battled to a 2-0 victory over the Eagles on April 3 through goals from Son Heung-min - earning him a place in the club's history books - and Christian Eriksen.
That win was much needed, ensuring that Mauricio Pochettino's side have their top-four fate in their own hands. After collecting one point from 15 between February 23 and March 31, anything less than victory over Palace would have been pretty disastrous.
As it is, though, the Lilywhites are now one point better off than North London rivals Arsenal in fifth place and a further two points in front of Manchester United. Third-placed Chelsea, meanwhile, can be overtaken if Tottenham win their game in hand.
Playing Champions League football at the Tottenham Hotspur Stadium next season is the big aim for chairman Daniel Levy, and his side can still achieve that through two avenues. As well as finding themselves in a strong position to finish third or fourth in the top flight, Tottenham may yet go on to win UEFA's showpiece competition this term.
That now has to be considered a serious possibility as Pochettino's men lead Man City 1-0 from Tuesday's quarter-final first leg in the English capital, courtesy of another goal from Son.
The win came at a cost as top scorer Harry Kane limped down the tunnel early in the second half and is possibly out for the rest of the season. The stats point out, however, that Spurs have dealt with Kane's absence just fine this term, largely thanks to the form of Son.
Playing before each of their top-four rivals this weekend, Tottenham now have a chance to continue building momentum in what is a huge week for the club - not just in terms of this season, but in context of their long-term future.
Recent form in Premier League: LLDLLW
Recent form (all competitions): DWLLWW
With their relegation confirmed in near-record time before the end of March, Huddersfield are left crossing off the games between now and the end of a dismal campaign.
Siewert is trying to take as many positives as he can from his side's performances, but they have now lost five in a row since picking up a last-gap victory over Wolverhampton Wanderers six weeks ago, most recently crashing to a 4-1 home defeat against Leicester City.
Going further back, it is 19 defeats in 21 matches, earning their only other point in a goalless draw with fellow strugglers Cardiff City on January 12 - also the only time they have avoided defeat in their last 10 away matches.
Huddersfield supporters will return to the Championship with plenty of happy memories, though, mainly from their maiden Premier League campaign, including a 2-1 win over Man United in October 2017.
Since then, the West Yorkshire outfit have lost 17 of their 19 league games against big-six opposition, collecting zero points from the last 30 on offer. However, their only two points in that 19-match winless run have come away from home - against Chelsea and Manchester City in May 2018 when dodging the drop.
With Tottenham, Liverpool and Man United still to play in their remaining six matches, it is unlikely that Huddersfield will restore any real pride before the end of the campaign.
A point in North London on Saturday will go a long way to giving supporters, and indeed Siewert, some hope to hold on to ahead of a big summer. On the basis of the last four months, though, simply avoiding a thrashing will be the immediate priority for Town.
Recent form in Premier League: WLLLLL
The ankle injury sustained by Kane in the win over Man City is expected to rule him out for the rest of the season. That leaves a big void to be filled up top, and Pochettino has a big decision to make.
Son is the preferred choice through the middle but, four days ahead of the return match with City, Pochettino may opt to rest the South Korean attacker against the Premier League's worst side.
After sitting out his side's last two games, Jonas Lossl could be recalled between the sticks in place of Ben Hamer, who has shipped 17 goals in just six Premier League appearances this season - one every 27 minutes on average.
Tottenham possible starting lineup:
Lloris; Trippier, Alderweireld, Sanchez, Davies; Wanyama, Sissoko, Skipp; Eriksen, Llorente, Lucas
Huddersfield possible starting lineup:
Lossl; Smith, Schindler, Kongolo, Durm; Billing, Hogg; Pritchard, Mooy, Lowe; Grant
Head To Head
Tottenham are unbeaten in eight matches in all competitions against Huddersfield, stretching back to a three-game losing streak between April 1955 and April 1956.
Town have lost all three of their Premier League meetings with Spurs by an aggregate score of 8-0, landing just nine shots on target during that run.
Only against Cardiff have Tottenham won their first four Prem games against a team without conceding a goal, which they can match against the Terriers this weekend.
We say: Tottenham 3-0 Huddersfield
Tottenham have played (57) and lost (13) more Premier League games against sides starting the day bottom of the table than any other team in the competition, most recently losing to West Bromwich Albion last May. There is little to suggest that Championship-bound Huddersfield can pull off an upset on Saturday, however, so we are backing a comfortable home win.