Here, Sports Mole looks at how the capital giants could line up when they welcome Brugge to the Bernabeu.
Zidane still has a problem at left-back with Ferland Mendy on the sidelines with a groin problem, while Marcelo has not played since the middle of the month due to a neck injury.
There is a chance that Marcelo could recover in time for this match, although the versatile Nacho is once again on standby to feature at left-back for the capital giants.
Elsewhere, Marco Asensio is still on the sidelines with a long-term knee injury, while Isco has not featured since the end of last month due to a hamstring complaint.
Luka Modric made his return from a thigh issue as a substitute against Atletico, though, and it is likely that the Croatia international could now be handed a spot in the starting XI.
Further forward, Vinicius Junior could replace Gareth Bale down the right, but Eden Hazard is expected to be handed another starting spot with the Belgian still looking for his first goal since arriving from Chelsea.
Zidane, though, has already shown this season that he is not afraid to make wholesale changes in order to keep players fresh - shuffling his pack for the league clash with Osasuna last week.body check tags ::