Saturday, March 27
Bristol (1) v Harlequins (3)
Bristol welcome back Fiji centre Semi Radradra from a knee injury in his first appearance since January. Ben Earl packs down at number eight following completion of the Six Nations, but full-back Max Malins is out with a thigh problem.
England centre Joe Marchant returns from the Six Nations to start in Harlequins' midfield alongside Andre Esterhuizen. Joe Marler, Scott Baldwin and Wilco Louw return en masse in the front row with Alex Dombrandt leading the team.
Last season: Bristol 28 Harlequins 15, Harlequins 22 Bristol 17
Last Six League Matches: Bristol W D W W W W Harlequins W W L W L W
Top try scorers: Ratu Naulago (Bristol) 7; Alex Dombrandt (Harlequins) 8
Top point scorers: Callum Sheedy (Bristol) 44; Marcus Smith (Harlequins) 173
London Irish (6) v Bath (7)
Nick Phipps is back as starting scrum-half for London Irish, rotating with Ben Meehan. Hooker Agustin Creevy drops to the bench where there is a place for returning Ireland flanker Sean O'Brien.
Charlie Ewels will captain Bath after returning from England duty with international team-mate Anthony Watson selected at full-back. Orlando Bailey makes his first start at fly-half because Rhys Priestland is out with a hamstring issue.
Last season: Bath 34 London Irish 17, London Irish 10 Bath 38
Last Six League Matches: London Irish L D W L W L Bath W W W L W W
Top try scorers: Curtis Rona (London Irish) 4; Tom Dunn (Bath) 6
Top point scorers: Paddy Jackson (London Irish) 116; Rhys Priestland (Bath) 112
Wasps (10) v Sale (4)
Wasps make four changes, among them the return of England scrum-half Dan Robson, who slots straight back in at nine. Alfie Barbeary makes his first start since recovering from a high ankle sprain.
Sale make six changes including a first start for rising scrum half Raffi Quirke. Lood De Jager is rested so Cobus Wiese comes in at lock. England flanker Tom Curry is rested.
Last season: Wasps 11 Sale 20, Sale 28 Wasps 18
Last Six League Matches: Wasps W L L L L W Sale L L W W L W
Top try scorers: Paolo Odogwu (Wasps) 5; Byron McGuigan & Marland Yarde (Sale) 4
Top point scorers: Jimmy Gopperth (Wasps) 52; Alan MacGinty (Sale) 130
Worcester (12) v Northampton (5)
England centre Ollie Lawrence makes his first appearance for Worcester since Boxing Day due to international commitments and injury. Tighthead prop Nick Schonert is back from a neck injury.
Northampton make seven changes including the immediate return of Dan Biggar from Wales duty. He is joined at half-back by Alex Mitchell, while Mitchell's England team-mate Dave Ribbans also starts.
Last season: Worcester 10 Northampton 16, Northampton 35 Worcester 16
Last Six League Matches: Worcester L L L L L L Northampton W W L L W L
Top try scorers: Perry Humphreys (Worcester) 5; Shaun Adendorff (Northampton) 4
Top point scorers: Billy Searle (Worcester) 41; James Grayson (Northampton) 54
Sunday, March 28
Leicester (8) v Newcastle (9)
Leicester pair George Ford and Richard Wigglesworth play together at half-back for the first time. Ford returns from England Six Nations duty alongside starting loosehead Ellis Genge. George Martin is on the bench.
Mark Wilson returns from England's Championship campaign to lead Newcastle. Luther Burrell continues his second spell in the Premiership at centre.
Last season: No corresponding fixture
Last Six League Matches: Leicester L W L W W L Newcastle L L W L L L
Top try scorers: Julian Montoya, Jasper Wiese & Tom Youngs (Leicester) 3; Gary Graham, Adam Radwan & Ben Stevenson (Newcastle) 3
Top point scorers: Zack Henry (Leicester) 84; Brett Connon (Newcastle) 37
