The match pits him against Spurs boss Mauricio Pochettino, who is reportedly the number one target for United to be the permanent successor to Jose Mourinho.
Solskjaer enjoyed a memorable victory against the north Londoners back in September 2001, as United recovered from a 3-0 half-time deficit to win 5-3, with the Norwegian introduced at the start of the second half.
Here, Press Association Sport delves into its picture archive to recall the match.
Dean Richards, centre, made the dream start to his Tottenham career as he put them 1-0 up (Kirsty Wigglesworth/PA)Les Ferdinand fired Spurs into a two-goal lead (Kirsty Wigglesworth/PA)Ferdinand and Teddy Sheringham congratulate Christian Ziege, on the ground, after his diving header made it 3-0 (Kirsty Wigglesworth/PA)Andy Cole's goal early in the second half gave United hope (Rebecca Naden/PA)Ruud van Nistelrooy, pictured, headed United level after Laurent Blanc had made it 3-2 (Kirsty Wigglesworth/PA)Juan Sebastian Veron, pictured, made it 4-3 to United, before David Beckham added the final goal of the match (Kirsty Wigglesworth/PA)
