Both teams made a winning return to league action last weekend, with Dortmund remaining within four points of top spot and Wolfsburg moving up to sixth.
Dortmund showed no signs of rustiness in seeing off local rivals Schalke 04 4-0 in their first game back following the coronavirus-enforced shutdown.
BVB were left to stew on a disappointing Champions League last-16 defeat to Paris Saint-Germain for two months, but they were quick to send out a message to Bayern last week.
Lucien Favre's side have now won five Bundesliga matches in a row, scoring 12 goals and conceding just once during that impressive run of results.
However, Bayern have also won five in a row and are four points better off at the summit with eight matches to go.
The good news for Dortmund is that one of those matches is against Bayern, with next week's Der Klassiker set to have plenty riding on it.
For that to happen, BVB need to keep their winning run going when they head to the Volkswagen Arena on Saturday.
The Wolves will certainly not make things easy for their opponents, having gone unbeaten in their last seven matches following on from a run of three defeats in a row.
A return of 15 points from the last 21 on offer has lifted Oliver Glasner's side into sixth, the same position that they finished in last season.
Not since gameweek nine have Wolfsburg held hold of one of the European spots, and the challenge now is to hold on to sixth.
That will not be easy as Freiburg and Schalke are within two points of them and Hoffenheim are a further two points adrift.
This is not a fixture the Wolves tend to do well in, though, having taken only one point from their last nine league meetings against Dortmund, including four home losses in a row.
Wolfsburg's Bundesliga form: DWWDDW
Wolfsburg's form (all competitions): WWDDLW
Borussia Dortmund's Bundesliga form: LWWWWW
Borussia Dortmund's form (all competitions): WWWWLW
As for Dortmund, Jadon Sancho has had another week to shake off a troublesome groin injury and should return to the starting lineup on Saturday.
Wolfsburg possible starting lineup:
Casteels; Mbabu, Knoche, Brooks, Otavio; Schlager, Arnold; Steffen, Mehmedi, Brekalo; Weghorst
Borussia Dortmund possible starting lineup:
Burki; Piszczek, Hummels, Akanji; Hakimi, Can, Brandt, Guerreiro; Sancho, Haaland, Hazard
We say: Wolfsburg 0-2 Borussia Dortmund
Wolfsburg may be in decent form, but they have a terrible recent record against Dortmund. In fact, the hosts have failed to score in any of their last six league encounters with BVB, so we are expecting this to end only one way.