While the home side could be eliminated from the competition with defeat, victory over the Spanish outfit would leave them one point off top spot in Group I.
With his side having performed consistently since his arrival in the summer, Villarreal boss Unai Emery would have been disappointed with the 1-1 draw against Maccabi Tel Aviv.
However, his second-string XI did enough to put the club on the brink of the last 32, and avoiding defeat in Turkey would ensure that the pressure is off heading into matchday six.
Having regularly rotated his squad for this competition, Emery's team selection is unlikely to change next week, but the Spaniard may feel that his players could benefit from a game with lower stakes.
Following their draw with La Liga champions Real Madrid, the Yellow Submarine recorded draws at Maccabi and domestic leaders Real Sociedad, extending an unbeaten record which has now reached 12 games.
Emery's main focus is on continuing to hold a top-four spot in Spain's top flight, but he will be eager for his much-changed team to make another positive impression in Turkey.
Sivasspor have been desperately poor on the domestic front with a five-match winless streak leaving the club down in 16th position.
Nevertheless, back-to-back victories over Qarabag FK have given Riza Calimbay's side a realistic chance of progressing to the knockout rounds of this competition for the first time in their history.
There will still be regret over how they imploded in the reverse fixture against Villarreal, conceding goals in quick succession at the start and end of the contest to lose 5-3.
However, that game proved that they are capable of scoring goals against higher-level opponents, and Olarenwaju Kayode is looking to add to his four goals from just 221 minutes in this competition.
Sivasspor Europa League form: LLWW
Sivasspor form (all competitions): DWLDWL
Villarreal Europa League form: WWWD
Villarreal form (all competitions): WWWDDD
Calimbay is expected to hand a recall to Kayode, who only started among the replacements against Qarabag last week.
Sivasspor possible starting lineup:
Samassa; Goiano, Appindangoye, Osmanpasa, Ciftci; Cofie, Claudemir; Gradel, Kone, Ninga; Kayode
Villarreal possible starting lineup:
Rulli; Pena, Foyth, Mori, Pedraza; Trigueros, Coquelin; Chukwueze, Baena, Kubo; Moreno
We say: Sivasspor 1-2 Villarreal
While the reverse fixture produced eight goals, supporters will expect a more tense affair on Thursday evening. However, Villarreal boast the better quality in all areas of the pitch, and we feel that the visitors will battle their way to a hard-fought win.