Los Che opened their new season with a 4-2 victory over Levante on September 13, while Celta shared the points in a goalless draw with Eibar in the campaign's opener on September 12.
Celta only just survived in the top flight during the 2019-20 campaign, ultimately finishing the season in 17th position, just one point clear of Leganes, who were relegated in 18th.
The Sky Blues could be in for another difficult season as it does appear that they will be heavily reliant on Iago Aspas for goals, particularly if they cannot sign another forward before the transfer window closes.
Oscar Garcia's side, who only won seven of their 38 league matches last term, opened their 2020-21 campaign with a goalless draw against Eibar on Saturday afternoon.
Celta will be keen to put three points on the board as soon as possible, but they have not won in their last eight league matches and struggled for invention in their season opener last weekend.
Now under the management of former Watford boss Javi Gracia, Valencia started their 2020-21 La Liga campaign with a 4-2 victory over Levante last weekend.
After back-to-back fourth-place finishes, Valencia ended last season in ninth, and it would be fair to say that it has been a busy transfer window for the club in terms of outgoings, with Rodrigo Moreno, Ferran Torres, Francis Coquelin and Dani Parejo amongst those to move on.
The former Spanish champions could lose more key players before the transfer window closes, but Gracia still has a very talented squad to work with, and he will be eyeing another three points this weekend.
Celta Vigo La Liga form: D
Valencia La Liga form: W
Celta Vigo possible starting lineup:
Villar; Mallo, Aidoo, Araujo, Olaza; Mendez, Yokuslu, Tapia; Mina, Aspas, Nolito
Valencia possible starting lineup:
Domenech; Wass, Gabriel, Mangala, Gaya; Soler, Kondogbia, Esquerdo, Guedes; Gomez, Vallejo
We say: Celta Vigo 1-2 Valencia
Valencia will view this match as another opportunity to put three points on the board, and we fancy the visitors to triumph this weekend. Aside from Aspas, it is difficult to see where the goals are coming from for Celta, who could struggle to make their mark against Los Che in this encounter.