The Potters are building towards the start of their 2020-21 Championship season against Millwall on September 12, while Blackpool will open their League One campaign away to Plymouth Argyle on the same day.
Stoke ended their 2019-20 Championship season with a 4-1 victory at Nottingham Forest on July 22, which saw them finish the campaign with 56 points, leaving them down in 15th position in the table.
There is no question that the supporters will be looking for improvement next term, but the Potters face a tough assignment on the opening weekend of the new Championship season as they head to Millwall.
Michael O'Neill's side have played three pre-season matches to date, beating Linfield and losing to Burton Albion before thumping Shrewsbury Town 5-1 at the club's training ground.
Former Chelsea midfielder John Obi Mikel made his first start for Stoke last time out, and the 33-year-old could be a key player for the club in the coming season.
The team's main focus in 2020-21 will be the league, but a run in the EFL Cup would certainly be welcomed, and the hosts will fancy their chances of booking their spot in the second round at Blackpool's expense.
Blackpool appointed former Liverpool Under-23 manager Neil Critchley as their new head coach at the start of March, but the 41-year-old only managed two games before the coronavirus outbreak led to the regular League One campaign being brought to a premature end.
As a result, the Seasiders have not been in competitive action since losing at home to Tranmere Rovers on March 10, but they have had plenty of pre-season games.
Indeed, the Tangerines have beaten Southport, Port Vale and Barrow in three of their five friendly matches, in addition to drawing with Everton and losing to Blackburn Rovers.
Critchley's side will face Barrow once again in the EFL Trophy on September 8 before starting their new League One campaign away to Plymouth Argyle on September 12.
Stoke City EFL Cup form: LWLWWL
Blackpool EFL Cup form: LWWWLL
As for Blackpool, Alex Fojticek could make his debut following his arrival from Manchester United, while Jordan Williams, Ethan Robson and Oliver Sarkic are also in line to make their first appearances for the club.
Stoke City possible starting lineup:
Butland; Collins, Shawcross, Martins Indi, Fox; Cousins, Mikel, Ince, Tymon; Afobe, Fletcher
Blackpool possible starting lineup:
Sims; Howe, Husband, Nottingham, Thorniley; Virtue, Devitt, Shaw, Robson; Feeney, Sarkic
We say: Stoke City 2-0 Blackpool
Blackpool are certainly capable of making it a difficult afternoon for Stoke, but we are finding it difficult to back against the home side, who have a lot of quality in the final third of the field. Afobe could join Fletcher as part of a front two this weekend, and the Potters should have too much for their opponents.