Michail Antonio has missed West Ham's last two matches and remains a fitness doubt for Sunday's clash, but David Moyes will give his only senior striker every chance of being available.
Arthur Masuaku, Andriy Yarmolenko and Angelo Ogbonna will definitely play no part for West Ham, while Darren Randolph and Fabian Balbuena are to be assessed.
With a big question mark over Antonio's availability, Moyes may well stick with the same side that eased past Sheffield United, which would mean Jarrod Bowen leading the attack.
As for Tottenham, Serge Aurier has been ruled out and fellow full-back Sergio Reguilon is also a major fitness doubt, having now missed more than a month.
Giovani Lo Celso is the visitors' only other confirmed injury or suspension absentee, with Jose Mourinho having plenty of other options to choose from in that position.
After being rested against Wolfsberger on Thursday, the likes of Harry Kane, Steven Bergwijn and Pierre-Emile Hojbjerg are expected to return to the starting lineup here.
Kane has scored 11 goals in 15 Premier League games against West Ham - only against Leicester City (14) has he scored more.
West Ham United possible starting lineup:
Fabianski; Diop, Dawson, Cresswell; Coufal, Soucek, Rice, Johnson; Lingard, Lanzini; Bowen
Tottenham Hotspur possible starting lineup:
Lloris; Tanganga, Alderweireld, Dier, Davies; Sissoko, Hojbjerg; Bergwijn, Ndombele, Son; Kane
