Spurs lost 1-0 to Royal Antwerp last time out and enter this match sitting second in Group J, three points better off than Ludogorets, who have lost both matches so far.
Jose Mourinho did not hold back after last week's surprise defeat in Belgium, admitting that he would have replaced all 11 of his starters at half time if he had the chance.
In the end he had to settle for making just the three changes, though it did not have the desired effect as Lior Refaelov's first-half strike proved the difference.
Spurs cruised to a 3-0 win over LASK Linz in their opening match, however, and they are expected to take six points from six in this double-header against Ludogorets.
Qualification for the knockout stages is all that matters for Mourinho in a competition that he has won twice with two different sides.
That loss to Antwerp aside, a game in which Spurs made nine changes to their lineup, the Lilywhites have been in good form of late.
Since squandering a three-goal lead to draw 3-3 with West Ham United, they have picked up three wins from the last four, keeping a clean sheet in two of those.
Sunday's late 1-0 win over Brighton and Hove Albion, secured through Gareth Bale's header 200 seconds after coming off the bench, moved Mourinho's men up to third in the league.
It is now about maintaining that momentum with three more points against Ludogorets, with this the first competitive meeting between the two clubs.
The home side lost 2-1 at home to Antwerp in their opening Group J fixture and were beaten 4-3 at LASK last time out, leaving them in desperate need of a point on Thursday.
Stanislav Genchev is in interim charge of the Eagles, who remain top of the Bulgarian First League thanks to their 1-0 win over Levski Sofia at the weekend.
Transferring their domestic form onto the continent is something Ludogorets have struggled with, though, having won only one of their last 11 home matches in the Europa League.
Ludogorets Razgrad Europa League form: LL
Ludogorets Razgrad form (all competitions): WDLWLW
Tottenham Hotspur Europa League form: WL
Tottenham Hotspur form (all competitions): WDWWLW
Mourinho has already confirmed that Bale will start Thursday's match as the Wales international continues to build up his match fitness.
Tottenham have near enough a fully-fit squad to choose from, the exception being full-back Japhet Tanganga, who is out with a thigh injury.
Summer signing Joe Rodon is also unavailable for this match as he was not registered in Spurs' Europa League squad.
As unhappy as Mourinho was with his players last week, rotation is once again expected against Ludogorets, with Dele Alli in line for a recall.
The hosts will be relying on Elvis Manu to help them pull off a shock victory over Tottenham, with the striker netting a hat-trick in last week's loss to LASK.
Ludogorets Razgrad possible starting lineup:
Iliev; Cicinho, Moti, Verdon, Nedyalkov; Andrianantenaina, Badjia, Santana; Tekpetey, Manu, Yankov
Tottenham Hotspur possible starting lineup:
Hart; Aurier, Sanchez, Dier, Davies; Lo Celso, Winks, Alli; Bale, Vinicius, Lucas
We say: Ludogorets Razgrad 0-2 Tottenham Hotspur
Tottenham may have suffered defeat to Antwerp last week but they will enter this match as strong favourites to overcome Bulgarian champions Ludogorets.
Changes can be expected but Spurs will still have a number of top-class talents in their lineup, with Bale among those looking to make an impact.