Vitolo has overcome a hamstring injury to start for defending champions Sevilla in their Europa League semi-final first leg away at Shakhtar Donetsk tonight.
The Spaniard returns in place of the injured Jose Antonio Reyes as Unai Emery makes three changes to the side that beat Real Betis 2-0 on Saturday.
Elsewhere, David Soria and Adil Rami come in for Sergio Rico and Timothee Kolodziejczak.
Shakhtar coach Mircea Lucescu, meanwhile, has gone with his tried and tested starting XI in recent Europa League matches.
Olexander Kucher, Maksim Malyshev, Taison, Marlos and Facundo Ferreyra all return for the home side.
Shakhtar Donetsk: Pyatov; Srna, Kucher, Rakitskiy, Ismaily; Malyshev, Stepanenko, Kovalenko; Marlos, Ferreyra, Taison
Subs: Kanibolotskiy, Shevchuk, Ordets, Wellington Nem, Bernard, Kobin, Eduardo
Sevilla: Soria; Mariano, Rami, Carrico, Escudero; N'Zonzi, Krychowiak; Konoplyanka, Banega, Vitolo; Gameiro
Subs: Rico, Kolodziejczak, Coke, Krohn-Dehli, Iborra, Cristoforo, Llorente
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