Los Blancos recorded an important 2-0 win over Inter Milan in the Champions League on Wednesday but have taken just one point from their last two league matches with Valencia and Villarreal.
Here, Sports Mole looks at how Madrid could line up on home soil.
Madrid will again be without the services of Sergio Ramos and Federico Valverde this weekend through injury, while Luka Jovic's recent coronavirus positive test will rule the striker out of contention.
Karim Benzema also remains a doubt with a groin problem, meaning that there could be another start in the final third of the field for Mariano Diaz.
There is a chance that Benzema could make his return on Saturday, although it seems more likely that the Frenchman will be saved for next week's Champions League clash with Shakhtar Donetsk.
Zidane is expected to shuffle his pack from the win over Inter, and there could be a return to the starting XI for Casemiro, with the Brazilian potentially joining Toni Kroos and Martin Odegaard in midfield.
Alvaro Odriozola remains a doubt for the reigning champions due to a troublesome calf problem, while Eder Militao has not featured since testing positive for coronavirus earlier this month and could miss out again.