Sevilla have won two, drawn one and lost two of their first five matches of the 2018-19 La Liga season, with a total of seven points leaving them in ninth position in the table.
Real Madrid, meanwhile, have collected 13 points from their five fixtures thus far, but were held to a 1-1 draw by Athletic Bilbao in their last away league match.
Stay tuned for live minute-by-minute coverage of the action.
SEVILLA: Vaclik; Carrico, Kjaer, Gomez; Navas, Banega, Sarabia, Arana; Vazquez; Silva, Ben Yedder
MADRID: Courtois; Nacho, Ramos, Varane, Marcelo; Modric, Casemiro, Kroos; Bale, Benzema, Asensio
Incredibly, Barcelona have lost at Leganes. As a result, a point would be enough for Real Madrid to move to the top of the table tonight. What a huge shock with the champions suffering defeat!