Real Madrid will be looking to halt Atletico Madrid's charge when Zinedine Zidane's side welcome their bitter rivals to the Alfredo Di Stefano Stadium on Saturday night.
Atletico are currently flying high at the top of La Liga and sit six points clear of fourth-placed Real Madrid, who have also played one game more than their bitter rivals.
Los Blancos will bring a two-game winning run into this weekend's contest, having followed a 1-0 success over Sevilla in the league last weekend with a 2-0 victory over Borussia Monchengladbach in the Champions League.
Here, Sports Mole looks at how Real Madrid could line up on home soil.
Out: Eden Hazard (muscle), Luka Jovic (adductor)
Doubtful: Federico Valverde (shin), Mariano Diaz (unspecified), Martin Odegaard (muscle)
> Click here for Real Madrid's latest injury and suspension news ahead of this match
Real Madrid will again be without the services of Eden Hazard and Luka Jovic for this weekend's contest, while Martin Odegaard and Mariano Diaz remain doubts for Zidane's side.
There is a chance that Federico Valverde could be involved as he is in the latter stages of his recovery from a shin injury, although it would be a surprise to see the midfielder thrown straight into the starting XI.
Sergio Ramos made his return from injury against Gladbach on Wednesday night and will now return to a league XI, while Dani Carvajal was on the bench for the Champions League fixture and should now return to the back four alongside Ramos, Raphael Varane and Ferland Mendy.
Karim Benzema scored a brace in the midweek European clash and will again lead the attack, while Vinicius Junior is expected to retain his position on the left.
There could be a change on the right of the attack with Marco Asensio potentially getting nod over Rodrygo Goes. Lucas Vazquez is also an option in that area of the field, though, with the Spaniard expected to be removed from the right-back spot to allow Carvajal to start.
> Click here to see how Atletico could line up for the contest
