Poznan, meanwhile, who host the Scottish side for the first time in their history, have already been eliminated from the competition.
Rangers cruised to a 4-0 victory away at Ross County in the Scottish Premiership on Sunday, which keeps up their magnificent run of form.
The Gers are unbeaten in their 25 matches played in all competitions this season with Steven Gerrard's side winning 21 of those games.
Rangers still have a task to complete on Thursday night as they aim to win their group ahead of Benfica, who have the same number of points.
Gerrard's men will finish top if they match or better Benfica's result against Standard Liege as they have a better head-to-head record over the Portuguese outfit.
Rangers' 1-0 win over Lech Poznan in October was their only previous encounter with the Polish side in a European competition.
The Gers travel to Poland having only won two of their last 19 away games in major European competitions – drawing 11 and losing the remaining six – although both wins were in the Europa League in 2020 against Braga in February and Standard Liege in October.
Lech Poznan's slim chances of progression from Group D were ended last week as they lost 4-0 away at Benfica, which confirmed their elimination from this season's Europa League.
The Polish side have struggled in the group stages this campaign as they have in their domestic league, where they currently sit eighth in the Ekstraklasa, 10 points behind Legia Warsaw, who lead the way.
Dariusz Zuraw's side did however bounce back from their loss to Benfica with a 4-0 win of their own against Podbeskidzie on Sunday.
Poznan head into their fixture with the Gers having lost all three of their major European matches against Scottish teams, losing twice against Alex Ferguson's Aberdeen side in the 1982-83 season and against Rangers this campaign.
Poznan have nothing to play for on Thursday night but Zuraw will use the game as an opportunity to build form to carry into the rest of their domestic season.
Lech Poznan Europa League form: LLWLL
Lech Poznan form (all competitions): LDLWLW
Rangers Europa League form: WWDDW
Rangers form (all competitions): WWDWWW
Left-back Borna Barisic – who along with Braga's Wenderson Galeno has the most Europa League assists since the start of the 2018-19 season, with eight – was an unused substitute against Ross County and is likely to return to the starting lineup to replace Calvin Bassey.
Lech Poznan defender Dorde Crnomarkovic is back from suspension and could feature on Thursday night.
Striker Mikael Ishak, who has scored four goals in his last five matches, is set to start up front once again.
Lech Poznan possible starting lineup:
Bednarek; Czerwinski, Satka, Rogne, Puchacz; Skoras, Tiba, Moder, Sykora; Ramirez; Ishak
Rangers possible starting lineup:
McGregor; Tavernier, Goldson, Balogun, Barasic; Arfield, Davies, Kamara; Roofe, Morelos, Kent
We say: Lech Poznan 0-2 Rangers
Rangers will be keen to top Group D in the hope of securing a supposedly easier draw in the last 32. Poznan were difficult to break down at Ibrox in October, but Gerrard's side should have enough quality and motivation to get the job done in Poland.