The Dragons have been in impressive form both domestically and in Europe, but they are still playing catch up on league leaders Sporting Lisbon.
It was the Dragons' third successive win in the competition without conceding and they will be confident of seeing the job through in their remaining two matches.
Focus now turns to domestic matters, and despite beating Portimonense 1-0 last time out, Sergio Conceicao's side are down in fourth place in the Primeira Liga.
Porto have dropped too many points on their travels, losing to Pacos de Ferreira and drawing against leaders Sporting in their last two outings, having ended last season with a 2-1 loss at Braga.
Next opponents Santa Clara have been tough to beat on their own patch, meanwhile, going four without defeat before Sporting won 2-1 at Estadio de Sao Miguel last time out.
The Azoreans are eighth in the 18-team division after six matches, one place above where they finished last season.
Daniel Ramos's side have lost their last seven meetings with Porto, however, including 2-0 defeats home and away in 2019-20.
A shock victory this weekend would see Santa Clara, who have a goal difference of zero, draw level on points with their opponents.
What should also be factored in, though, is that Porto had to travel to France to play on Wednesday night, whereas Santa Clara have had a six-day rest period between games.
Santa Clara Primeira Liga form: WDLLWL
Santa Clara form (all competitions): DLLWLW
Porto Primeira Liga form: WLDWLW
Porto form (all competitions): WLWWWW
Veteran defender Pepe has been nursing a heel injury and is not expected to play any part against Santa Clara.
Midfielder Mateus Uribe is Porto's only other real fitness doubt and is unlikely to be risked.
Thiago Santana has six goals in seven league matches this season, making him the joint-second top scorer in the division, and is certain to lead the line.
Santa Clara possible starting lineup:
Pereira; Ramos, Cardoso, Afonso, Villanueva, Mansur; Lincoln, Carvalho, Rashid, Ukra; Santana
Porto possible starting lineup:
Marchesin; Manafa, Mbemba, Sarr, Sanusi; Vieira, Otavio, Oliveira; Corona, Taremi, Marega
We say: Santa Clara 0-2 Porto
Porto have found some form with four wins in a row in all competitions. Santa Clara have lost only one of their last five home matches - against league leaders Sporting - but the visitors will surely have enough firepower to pick up the points this weekend.