Cuthbert had been sidelined by injury but he returns for the clash at London Road, with Gary Sawyer dropping to the substitutes' bench.
After making sweeping changes for his side's final league fixture against Port Vale, boss Darren Ferguson reverts to his first-choice lineup for the visit of Orient.
PETERBOROUGH UNITED XI: Olejnik, Alcock, Ntlhe, Baldwin, Bostwick, Swanson, Payne, Assombalonga, Rowe, Ajose, Little
LEYTON ORIENT XI: Jones, Omozusi, Vincelot, Cuthbert, Baudry, Cox, Lisbie, Mooney, Odubajo, Clarke, Lundstram
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