Western United are currently winless so far, with one draw and one defeat in their opening two games, while the visitors are coming off a midweek 5-3 thumping of Adelaide United.
After a prolonged delay to the start of their league campaign, Perth Glory finally opened their season with a blast, as they put five past Adelaide United to grab an emphatic 5-3 victory on Wednesday.
The Glory showed no signs of rustiness, as they secured their first win in six matches, after a disappointing AFC Champions League run, where they finished last in Group F with four losses in five outings.
Australian-born striker Nick D'Agostino scored in each half of the game, while Neil Kilkenny, Andy Keogh and substitute Carlo Armiento also got on the scoresheet in what was a superb display of attacking dominance.
It was also a dream start to life in the Australian league for head coach Richard Garcia, who was appointed in the summer, as he watched his side deliver a five-star performance on his league debut.
The former Socceroo took over from Anthony Popovic, who moved to Greek-based club Xanthi, following a two-year reign at the HBF Park.
The hosts, on the other hand, will be aiming to get up and running when they return to Geelong on Saturday, after stumbling into the new season.
Western United and Perth Glory have only ever met twice, with the hosts having a slight advantage, after securing one win and a draw in the two meetings last season.
Western United Australian A-League form: DL
Perth Glory Australian A-League form: W
Defender Joshua Risdon has not featured since the 2-0 loss to Melbourne City in August due to a tibia injury, and he is the only guaranteed absentee for this fixture.
Club captain Diego Castro remains a doubt and will be assessed, having missed the trip to Melbourne City with a minor leg injury.
Western United possible starting lineup:
Kurto; Calver, Uskok, Vujica; Imai, Lustica, Sanchez, Pain; Diamanti, Guarrotxena, Berisha
Perth Glory possible starting lineup:
Reddy; Ingham, Lachman, Aspropotamitis, Rawlins; Stynes, Timmins, Kilkenny, D'Agostino; Fornaroli, Keogh
We say: Western United 1-2 Perth Glory
After contrasting starts to the new campaign, this fixture will be a close one, however, Perth Glory are the better team currently, and they should be able to build on their excellent midweek display and steal all three points on Saturday, bringing an end to their winless run against the hosts.