There had been suggestions that this match could be postponed after Nimes confirmed four cases of coronavirus in their squad, but the contest is, as it stands, due to go ahead on Sunday afternoon.
Nimes were 18th in the Ligue 1 table when the 2019-20 campaign was postponed, having picked up just seven wins from their 28 matches during a disappointing season.
Les Crocodiles managed to secure their spot at this level for at least one more year, though, and will be keen to open their 2020-21 season in a positive fashion on Sunday afternoon.
Nimes have had friendlies against Strasbourg, Grenoble Foot 38 and Rodez since the end of July, but they have not been in competitive action since a 2-1 defeat to Metz at the start of March.
As mentioned, there had been fears that this game would be suspended after four cases of coronavirus were confirmed in Nimes' first-team squad, but all four players have been quarantined, and the match is going ahead as it stands.
Jerome Arpinon's side have actually lost their last three competitive encounters, but they recorded four straight victories between February 1 and February 15 and are certainly capable of causing Brest problems in this game.
Brest, meanwhile, were 14th in Ligue 1 when the 2019-20 campaign was called to a halt due to the coronavirus outbreak, having won eight, drawn 10 and lost 10 of their 28 matches.
Les Pirates only returned to France's top flight for 2019-20 courtesy of finishing second in Ligue 2 the season before and therefore consolidating at this level is currently their priority.
Olivier Dall'Oglio's side, who have lost their last four matches against Nimes in all competitions, have not been in competitive action since a 1-0 loss to Reims on March 7.
They have played four friendlies over the last few weeks, though, recording victories over Stade Briochin and Guingamp, in addition to drawing with Lorient and losing against Rennes.
Brest have actually only won one of their last nine away games in Ligue 1 and have failed to score in five of their last seven matches on their travels, which will not fill their supporters with too much confidence.
Nimes pre-season form: LLD
Brest pre-season form: WDLW
Nimes are expected to hand a debut to 29-year-old goalkeeper Baptiste Reynet, who arrived from Toulouse this summer, while fellow new arrivals Andres Cubas, Yassine Benrahou and Birger Meling could also start.
Romain Philippoteaux was only a substitute in his side's last competitive match against Metz, but the attacker could come into the side for this game, while Lucas Deaux should keep his spot in midfield.
As for Brest, a busy summer transfer window has seen the likes of Franck Honorat, Christopher Herelle and Heriberto Tavares all arrive, and the trio should go straight into the starting side for this game.
Nimes possible starting lineup:
Reynet; Ripart, Landre, Birancon, Meling; Deaux, Cubas; Philippoteaux, Benrahou, Ferhat; Roux
Brest possible starting lineup:
Larsonneur; Pierre-Gabriel, Herelle, Duverne, Perraud; Honorat, Diallo, Battocchio, Tavares; Cardona; Charbonnier
We say: Nimes 1-1 Brest
Both teams will be desperate to get their campaigns off to a winning start, but a draw would not be the worst result in the world. There should be a number of new players on display in this particular game, and we are struggling to separate the two sides on the afternoon.