The visitors head into the contest holding a one-point advantage over their hosts, whose 2-0 defeat in Italy gifted Gli Azzurri control of League A Group 1.
With Sunday's 3-1 victory over Bosnia-Herzegovina representing his first win as Netherlands boss, Frank de Boer will be relieved that some of the pressure has eased on his side's progress on the international scene.
However, this group of players has been trending in the right direction since last month's draw in Italy, and De Boer will be optimistic that Oranje can at least finish in second position in this group.
Unless Bosnia-Herzegovina can pull off a shock against Italy, that is the best that Netherlands can hope for, but this group of players would take the positives if they can extend their unbeaten streak to five matches.
The long-term absence of captain Virgil van Dijk remains a blow, although an injury to fellow centre-back Nathan Ake has resulted in other defenders being forced to step up during an important period.
Georginio Wijnaldum responded to being handed the skipper's armband by netting an early double on Sunday, his first international goals of the year after scoring eight times during 2019.
As far as Poland are concerned, they need to find a response to losing their grip of top spot in the group courtesy of the setback in Italy.
A draw would have been enough to put Jerzy Brzeczek's side in a favourable position ahead of their next outing, but Bialo-czerwoni were well beaten in Reggio.
The result ended a run of three games without conceding a goal, but Brzeczek will be placing far more emphasis on attack in this game as they bid to give themselves every chance of regaining first position.
Given their inferior head-to-head record with Italy, only a win over Netherlands and success for Bosnia-Herzegovina over Italy will provide them with progress into the Finals.
Poland Nations League form: LWDWL
Poland form (all competitions): WWDWWL
Netherlands Nations League form: WLDDW
Netherlands form (all competitions): LLDDDW
Brzeczek will be unable to call upon Jacek Goralski, who was sent off after being introduced as a substitute on Sunday.
Poland possible starting lineup:
Szczesny; Bereszynski, Glik, Bednarek, Reca; Krychowiak, Moder; Szymanski, Linetty, Grosicki; Lewandowski
Netherlands possible starting lineup:
Krul; Dumfries, De Vrij, Blind, Wijndal; Van de Beek, Wijnaldum, F.De Jong; Berghuis, Malen, Depay
We say: Poland 1-1 Netherlands
Both teams will head into this fixture looking for maximum points, while hoping that Bosnia-Herzegovina can do them a favour elsewhere. However, there is a realistic chance of second spot being the best that either side can hope for, and that could lead to the visitors doing enough for a share of the spoils.