Meanwhile, after back-to-back defeats, Middlesbrough travel to The Den sitting in the relegation zone with just five matches remaining.
When Middlesbrough comfortably defeated Stoke City at the end of June, many would have felt that Neil Warnock's instant effect at the North-East outfit would have been long-lasting.
However, defeats to Hull City and Queens Park Rangers, game in which they were regarded as the favourites, have led to Boro dropping back down into the bottom three.
Although they play before some of their nearest rivals on Wednesday, Warnock knows that another negative result could leave Boro cut adrift if other scorelines do not go their way over the coming days.
The veteran boss has spoken highly of his side's recent commitment, but they will not survive in the second tier unless they improve significantly in the final third.
From Millwall's perspective, they will feel that this fixture has come at the perfect time as they bid to become a factor in the race for the top six.
While Gary Rowett will take the positives from a return of five points from three matches, it has not been enough to keep pace with the likes of Cardiff City and Derby County.
However, the London outfit arguably have the most favourable run-in of the clubs around them, and Rowett will be optimistic that five straight wins will earn a place in the playoffs.
Whether that is realistic remains to be seen, but Jake Cooper's late winner at Charlton Athletic on Friday night could act as the catalyst for a late upturn in results.
Millwall Championship form: DWLDDW
Middlesbrough Championship form: DWLWLL
With Millwall potentially using a 3-4-3 strategy, it appears unlikely that Warnock will persist with a narrow formation.
Marcus Tavernier will also feel that he is due a start after three substitute outings in a row.
Millwall possible starting lineup:
Bialkowski; Hutchinson, Cooper, Pearce; Romeo, Thompson, Woods, M.Wallace; J.Wallace, Smith, Bradshaw
Middlesbrough possible starting lineup:
Stojanovic; Spence, Fry, Moukoudi, Johnson; Wing, McNair, Saville; Tavernier, Fletcher, Roberts
We say: Millwall 2-1 Middlesbrough
All things considered, this should be a tense, low-scoring affair. With Millwall having the momentum after their late win at Charlton, we can only back the Lions to edge out their struggling opponents.