The hosts have lost all three matches so far this season, including a last-minute defeat at the hands of Paris Saint-Germain, while Reims have collected a solitary point.
Metz were seconds away from holding PSG to a goalless draw in their most recent outing, only for Julian Draxler to pop up deep in injury time for the 10-man champions.
It was a cruel blow for Les Grenats, who are now on their longest losing streak in a year and in desperate need of a positive result this weekend to kickstart their campaign.
Reims have hardly made the best of starts, either, sitting one point and one place above their opponents just outside the relegation zone.
David Guion's charges chucked away a two-goal lead to draw 2-2 with Monaco on the opening weekend, before losing 1-0 against Lille and Angers in their last two league outings.
However, the Red and Whites put those disappointing results behind them on Thursday as they kicked off their Europa League adventure with a second-qualifying round win at Servette.
European football is Reims' reward for finishing sixth last time out, but they are already a long way from those heights with three games of 2020-21 played.
On the face of it, this could be the ideal fixture for Reims to carry that European momentum into their domestic season, with Metz losing three of their last four home games.
That is as many defeats as they suffered in their previous 11 at Stade Saint-Symphorien, and Vincent Hognon's charges are the only side yet to score in the first three rounds, losing 1-0 to Monaco, Lille and PSG.
However, Metz are unbeaten in their last 10 games against Reims in Ligue 1 - their best current run against a Ligue 1 opponent, winning seven of those.
Metz Ligue 1 form: LLL
Reims Ligue 1 form: DLL
Reims form (all competitions): DLLW
Hognon is expected to change formation and personnel on the back of the late loss at PSG, having gone with five across the back at the Parc des Princes.
Metz goalkeeper Alexandre Oukidja has made 114 saves since the start of last season in Ligue 1, which is more than any other goalkeeper over that period.
Yunis Abdelhamid is Reims' other confirmed absentee after recently testing positive for coronavirus.
Boulaye Dia, who has one goal in three games this term, is expected to start through the middle in a 4-3-3 formation.
Metz possible starting lineup:
Oukidja; Centonze, Bronn, Boye, Udol; Maiga, Angban, Pajot; Boulaya, Niane, Nguette
Reims possible starting lineup:
Rajkovic; Foket, Munetsi, Marseic, Konan; Chavalerin, Cassama, Berisha; Zeneli, Dia, Cafaro
We say: Metz 0-1 Reims
Metz have struggled at home and Reims are winless in five matches on their travels in Ligue 1. After picking up a morale-boosting victory in Europe on Thursday, though, we are going with an away win in this contest.