Niko Kovac's side recovered from two goals down to draw 2-2 with Reims on the opening weekend, while Metz are in action for the first time this season.
Former Bayern Munich boss Kovac was heading for defeat in his first competitive match as Monaco head coach, his side finding themselves two goals down to Reims early on.
That game marked Monaco's first competitive match back in five months due to the coronavirus pandemic, which brought an early end to the 2019-20 campaign.
The principality club finished ninth in the points-per-game table and just outside a European spot, which will be Kovac's target for this season.
Metz were six places and six points worse off than Monaco last term, but they have built some momentum during pre-season with three victories on the spin.
In fact, Metz ended the shortened 2019-20 campaign fairly strongly, losing just two of their last 11 games - against Bordeaux (2-1) and Lyon (2-0), both in February.
Monaco have similarly made themselves tough to beat, losing one of their last seven Ligue 1 games. However, they have won just one of their last six away matches.
Things have already changed since Kovac replaced Robert Moreno in July, with Monaco registering the highest possession rate and highest passing accuracy of any side on matchday one.
Kovac's men ultimately came away from that Reims clash with just a single point, though, and a repeat of that result this weekend would be considered a disappointing outcome.
Metz' pre-season form: WWLWWW
Monaco Ligue 1 form: D
Monaco form (including pre-season): WLDWD
Sofiane Diop replaced Henry Onyekuru at half time against Reims and may have done enough to earn a starting spot for Monaco this weekend.
As for Metz, Vagner is in contention for a competitive debut after joining from Saint-Etienne in the summer.
Vincent Pajot is likely to be handed a start, the midfielder having assisted three of Metz' last six goals in Ligue 1.
Metz possible starting lineup:
Oukidja; Centonze, Bronn, Boye, Udol; Maiga, Angban, Pajot; Boulaya, Niane, Vagner
Monaco possible starting lineup:
Lecomte; Aguilar, Disasi, Mukinayi, Ballo-Toure; Fofana, Tchouameni, Golovin; Martins, Ben Yedder, Diop
We say: Metz 1-2 Monaco
Monaco arguably have a slight advantage heading into this match, having already got one competitive outing under their belt. The visitors also boast an impressive record in this fixture, winning eight of the last nine Ligue 1 encounters, so we are backing them to come out on top this weekend.