Following their midweek Champions League exit at the hands of Barcelona, the Premier League is now the only remaining route into next season's competition for the Red Devils, but they are currently losing the race.
Two points separate Ole Gunnar Solskjaer's side from the top four, and their run of five defeats from their last seven outings is threatening to derail the good work they did in the immediate aftermath of the Norwegian's arrival.
Here, Sports Mole looks at how United could line up for Sunday's trip to Merseyside.
Solskjaer has had some stern words for his players following another defeat in midweek, which could hint at possible changes from Tuesday's match in Barcelona.
Luke Shaw remains suspended having picked up 10 Premier League yellow cards this season, meaning that Ashley Young is likely to continue on the left with Diogo Dalot perhaps coming in on the opposite flank in place of Phil Jones.
United could be boosted by the returns of Nemanja Matic - an unused sub against Barcelona - and Ander Herrera, who is now back in training and is expected to be in contention for this weekend's match.
Eric Bailly is expected back in training this weekend following concussion, but this match may come too soon for him to start while Antonio Valencia remains sidelined with a muscle problem.