Both teams walked away with a point from their most recent encounters, with Man United drawing at Leicester while Wolves held Tottenham to a 1-1 stalemate on Sunday evening.
Manchester United's away record in the top flight is nothing short of sensational, and Leicester City were facing an uphill battle to be the ones to end the Red Devils' 10-game Premier League winning streak on the road.
Boxing Day's clash between two Champions League-chasing sides lived up to its billing, and despite going 2-1 up thanks to goals from Marcus Rashford and Bruno Fernandes, a late Axel Tuanzebe own goal ensured that Leicester walked away with a point after Harvey Barnes had initially levelled the scores.
Even though United were unable to stretch their winning away record in the top flight to 11 matches, Arsenal did Ole Gunnar Solskjaer's men a favour by beating Chelsea a few hours later, meaning that Man United remain in the Champions League places for the time being.
Furthermore, that point at the King Power Stadium saw the Red Devils extend their unbeaten run in the Premier League to eight matches, with United finally starting to produce the goods on their own turf after struggling in the early stages of the season.
Solskjaer's men have taken seven points from a possible nine in their last three home league matches, and United fans will not be able to forget that 6-2 thrashing of Leeds in a hurry, but the visit of Wolves represents a much sterner test for Man United.
Meanwhile, Wolverhampton Wanderers welcomed Tottenham Hotspur to a ground where they had overcome Chelsea just a couple of weeks before, although Nuno Espirito Santo's side could not get the better of Burnley at Turf Moor before the festive weekend.
The West Midlands outfit failed to return to winning ways on their own patch, but the Wolves faithful will no doubt be satisfied with a point after witnessing their side hold Tottenham to a 1-1 draw on Sunday evening.
The reinvigorated Tanguy Ndombele opened the scoring for Spurs, but Romain Saiss's late header ensured that Wolves walked away with a deserved point, although Santo would have felt frustrated not to have taken all three against a stuttering Tottenham outfit.
Fabio Silva spurned a terrific chance to win the game right at the death, and that point against Jose Mourinho's side sees Wolves overtake Leeds to sit in 11th spot after 15 matches, with the West Midlands outfit now five points adrift of the European places.
United and Wolves met four times across all competitions last season - with three of those ties ending in draws - and the Red Devils have only managed to win one of their last seven games with Wolves in the Premier League and FA Cup.
Manchester United Premier League form: WWDWWD
Manchester United form (all competitions): LDWWWD
Wolverhampton Wanderers Premier League form: WLLWLD
Victor Lindelof was unable to play through the pain against Leicester as his chronic back problem forced him off in the second period, and the makeshift right-back is not expected to feature on Tuesday.
The Red Devils have not disclosed details regarding Aaron Wan-Bissaka's injury, but with the defender also a doubt here, Tuanzebe should be given the chance to redeem himself with a start against Wolves.
Changes could be afoot with only 72 hours in between matches, with Edinson Cavani - who provided the assist for Fernandes's 10th league goal of the season on Boxing Day - potentially in line to spearhead the attack in place of Anthony Martial.
Manchester United possible starting lineup:
De Gea; Tuanzebe, Maguire, Bailly, Telles; Fred, McTominay; Greenwood, Fernandes, Rashford; Cavani
Wolverhampton Wanderers possible starting lineup:
Patricio; Semedo, Coady, Saiss, Ait Nouri; Neves, Moutinho; Traore, Podence, Neto; Silva
We say: Manchester United 2-1 Wolverhampton Wanderers
United have had an extra day off to recover from their hard-fought draw at the weekend, and the Red Devils boast a much stronger bench than Wolves do amid their injury problems. Santo's men fully deserved their point against Spurs and arguably should have taken all three, but United will offer a far greater attacking threat and Solskjaer's men should come up trumps at Old Trafford, but it is sure to be close.
Top betting tip
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