United are likely to field several of their fringe and emerging players against a side who are currently 17th in League One, although coach Ole Gunnar Solskjaer will be hoping his understudies prove more clinical than they did in the narrow 1-0 Europa League win against Astana.
Solskjaer is short of forward options after Marcus Rashford, who led the line against Astana, limped off with a thigh injury at the London Stadium.
Here, Sports Mole looks at how the Red Devils could line up for Wednesday's match.
Jesse Lingard replaced Rashford at West Ham after his England teammate made a wincing departure from the defeat, although Solskjaer might not be entirely comfortable risking another of his senior strikers for 90 minutes in a match United should stroll.
Greenwood scored his first senior goal for the club with the winner against Astana and the 17-year-old could be given the chance to add to his account if he recovers from the bout of tonsillitis that kept him out at the weekend.
Back-up goalkeeper Sergio Romero will hope to avoid a repeat of the straight red card that led to United's downfall when they lost on penalties to Derby County at Old Trafford in this competition last season, when defender Phil Jones missed the decisive spot kick.
Among the youngsters who could feature, defender Axel Tuanzebe was born in Rochdale and made his first senior appearance for more than two years against Astana.body check tags ::