Liverpool vs. Bournemouth (Saturday, 12.30pm)
Jurgen Klopp's side have lost three of their last four games across all competitions but are firm favourites to get their campaign back on track against a Bournemouth side who sit inside the bottom three with 10 games of the season remaining.
We say: Liverpool 2-0 Bournemouth
On paper, this looks to be the ideal fixture for Liverpool to get themselves back on track. They have a formidable record against Bournemouth, have been almost unstoppable at Anfield this season and take on a Cherries side in poor form struggling against relegation.
Of course, last weekend's Watford defeat proves that nothing can be taken for granted, but we cannot see anything other than a Liverpool return to winning ways on Saturday.
Arsenal vs. West Ham (Saturday, 3pm)
The Gunners go into the weekend's clash five points off fifth-placed Manchester United, while West Ham are only above the relegation zone on goal difference.
We say: Arsenal 2-0 West Ham United
West Ham are visiting a ground where they have shipped a hefty amount of goals over the past few years, and given Arsenal's quality in attack and improved defensive record, we are going for a comfortable home win.
Crystal Palace vs. Watford (Saturday, 3pm)
The Hornets became the first Premier League team to beat Liverpool this season when they triumphed last time out, but Nigel Pearson's side are still 17th in the table, five positions behind Palace.
We say: Palace 1-1 Watford
These two teams shared the points earlier this season, and we are finding it difficult to separate them once again. We fancy a low-scoring draw at Selhurst Park on Saturday afternoon.
Sheffield United vs. Norwich (Saturday, 3pm)
We say: Sheffield United 1-0 Norwich City
Norwich will arrive at Bramall Lane full of confidence, but it is difficult to look past Sheffield United due to their form this term; we expect the Blades to put another three points on the board.
Southampton vs. Newcastle (Saturday, 3pm)
While the Saints have lost three out of their last four outings, the Magpies are without a top-flight victory in five attempts.
We say: Southampton 2-1 Newcastle United
Although Newcastle will have more belief after their display in midweek, Southampton are well rested for an important game in their season. We feel that, and Newcastle's second trip south in the space of a few days, could prove crucial at St Mary's.
Wolves vs. Brighton (Saturday, 3pm)
As for Brighton, they make the trip to Molineux sitting just one point above the relegation zone after a disappointing period in the top flight.
We say: Wolverhampton Wanderers 1-1 Brighton & Hove Albion
While Wolves are the clear favourites to win this game, the stakes are rising as they bid to earn European football next season. We feel that could play into Brighton's favour, who had success in the final third in the reverse fixture late last year.
Burnley vs. Tottenham (Saturday, 5.30pm)
Tottenham Hotspur will be looking to get their season back on track when they face Burnley at Turf Moor in Saturday's late Premier League kickoff.
Spurs were knocked out of the FA Cup by Norwich City in midweek and have lost four games in a row, leaving their campaign on the brink of tatters.
We say: Burnley 1-1 Tottenham Hotspur
Burnley enter this match in far better form than Tottenham and can overtake their opponents in the table with victory at Turf Moor. Mourinho needs to stop the rot and a point in Lancashire will likely be welcomed ahead of a big clash with Leipzig next week.
Chelsea vs. Everton (Sunday, 2pm)
Although the Toffees currently sit in 11th place, Carlo Ancelotti returns to Stamford Bridge knowing that victory will take his side to within five points of Sunday's opponents.
We say: Chelsea 2-2 Everton
This has all the makings of a back-and-forth contest. Neither side has impressed at the back of late, and that should lead to goals in West London. With both teams possessing quality in the final third, we feel that an entertaining draw will be played out at Stamford Bridge.
Manchester United vs. Man City (Sunday, 4.30pm)
Local rivals Manchester United and Manchester City will meet for the fourth time in the space of three months this weekend when the Red Devils welcome the reigning champions to Old Trafford on Sunday.
United currently boast the bragging rights for the season with two wins to one, but they sit 15 points behind Sunday's visitors in the Premier League table and know that anything other than a victory could harm their hopes of qualifying for next season's Champions League.
We say: Man United 2-2 Man City
There have only been two draws in the last 24 editions of this derby across all competitions, but with both sides coming into the match in good form we can see them cancelling each other out.
United certainly need the win more than City in terms of their league aspirations this season, but the away team has dominated this fixture in recent years and we are backing Guardiola's side to come away with a share of the spoils on Sunday.
Leicester vs. Aston Villa (Monday, 8pm)
Dean Smith's side are currently 19th in the table but sit just two points from the safety of 17th and will be looking to overcome a Leicester side that are without a league victory since January 22.
We say: Leicester 2-1 Aston Villa
Leicester's form has not exactly been terrific in recent weeks, but the Foxes are due a win. Villa played well against Man City in the EFL Cup final but have the second-worst away record in the Premier League this season. As a result, we are finding it hard to back against the hosts, who should have enough to triumph.