Pochettino named a near-full strength side for the midweek EFL Cup win over Chelsea, and he is unlikely to make too many changes for this match.
Captain Hugo Lloris will return in goal, while the likes of Ben Davies and Erik Lamela may also be hopeful of working their way into the starting XI after being on the bench last time out.
The in-form Son Heung-min is expected to lead the line in what will be his final game before joining up with South Korea at the Asian Cup.
There is also an outside chance that Eric Dier could return to the squad following surgery to remove his appendix last month, while Jan Vertonghen is also closing in on a comeback and Lucas Moura will be assessed before kickoff.
Mousa Dembele could also be in contention following an ankle injury, although the possibility of a January move to China could mean that he has played his final game for the club.