The Belgium international returned to training on Tuesday following more than two weeks out with an ankle injury sustained in the 2-1 win over Arsenal.
In Lukaku's absence, United have managed just one goal in three games - picking up victory in one of those - and will therefore give the 25-year-old every chance of making Saturday evening's clash.
Here, Sports Mole looks at the striker's record against Chelsea during his time with Man United and Everton.
Having been loaned to West Bromwich Albion and Everton, Lukaku's first appearance against his former club did not come until August 2014 when playing 89 minutes of the Toffees' 6-3 home defeat.
That was the first of a seven-game scoreless streak against the Blues, in fact, taking in six games with Everton and one with Man United.
The most recent of those goalless outings was November's 1-0 loss at Stamford Bridge, but Lukaku did end that scoring duck a little under three months ago.
Lukaku got in front of Marcos Alonso for his first goal against he ex-employers at the eighth time of asking, while also providing his first assist by setting up Jesse Lingard in the 2-1 victory at Old Trafford.